Target Protein Ligand-Linker Conjugates
Target Protein Ligand-Linker Conjugate incorporates a ligand for the target protein and a linker. When binding to an E3 ligase ligand, the conjugate will be a PROTAC with ability to induce ubiquitylation and subsequent degradation the protein of interest.
Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases, transcription factors, epigenetic tools and E3 ligase themselves.
The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
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Target Protein Ligand-Linker Conjugates Related Products (135)
Related Products (135)
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ER ligand-9
0 ImagesCat. No.: HY-172067CAS No.: 3026011-20-8ER ligand-9 is a conjugate of an estrogen receptor (Estrogen Receptor/ERR) and a linker, which can be used to synthesize PROTAC ERD-1233 (HY-169367).
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PD-1 ligand-2
0 ImagesCat. No.: HY-175901APD-1 ligand-2 is a target protein ligand-linker conjugate that can be used in studies related to PROTAC synthesis, such as serving as the target protein ligand-linker conjugate for (Rac)-EBET-1055 (HY-161346A).
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Palbociclib-C4-Boc
0 ImagesCat. No.: HY-176365CAS No.: 2139329-48-7Palbociclib-C4-Boc is a Target Protein Ligand-Linker Conjugate that incorporates a ligand for CDK4/6 Palbociclib (HY-50767) and a PROTAC linker (HY-W007803), which recruits E3 ligases. Palbociclib-C4-Boc can be used for synthesis of PROTAC BSJ-03-204 (HY-136250).
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BLIMP-1 ligand-Linker Conjugate 1
0 ImagesCat. No.: HY-180179BLIMP-1 Ligand-Linker Conjugate 1 is a conjugate of BLIMP-1 Ligand-1 (HY-180178) and Linker (HY-180180). BLIMP-1 ligand-Linker Conjugate 1 can be coupled with CRBN ligand-881 (HY-W442918) to form PROTAC BLIMP-1 degrader-1 (HY-180177).
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Oxide-DFHBI-demethyl-C6-NH2
0 ImagesCat. No.: HY-176802Oxide-DFHBI-demethyl-C6-NH2 is a Target Protein Ligand-Linker Conjugate that incorporates a target aptamer ligand (HY-176801) and a PROTAC linker (HY-79577), which recruits E3 ligases. Oxide-DFHBI-demethyl-C6-NH2 can be used for synthesis of RNA aptamer-based PROTAC Dth (HY-175397).
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EN884
0 ImagesCat. No.: HY-163019CAS No.: 2189497-60-5EN884 is a BRD4 degrader via a SKP1- and proteasome-dependent manner. EN884 can be used in synthetic proteolysis targeting chimeras (PROTACs).
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HPK1 ligand-Linker Conjugate 1
0 ImagesCat. No.: HY-175551CAS No.: 3061690-80-7
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JQ-1 (carboxylic acid)-NH-C8-COOH
0 ImagesCat. No.: HY-178519CAS No.: 2918972-18-4JQ-1 (carboxylic acid)-NH-C8-COOH is a synthetic target protein ligand-conjugate linker, which can be used to synthesize JQ1-S(GlcNAc)Cq (HY-178510). JQ1-S(GlcNAc)Cq is a potent Sugar-Coated PROTAC bifunctional degrader with anti-tumor activity.
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ATR ligand 2-CO-Ph-COOH
0 ImagesCat. No.: HY-182018CAS No.: 3126270-19-4
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BRD4 ligand-Linker Conjugate 8
0 ImagesCat. No.: HY-186268CAS No.: 3034180-15-6BRD4 ligand-Linker Conjugate 8 is a Target Protein Ligand-Linker Conjugate that can be used in studies related to PROTAC synthesis. BRD4 ligand-Linker Conjugate 8 is applicable for the synthesis of BD-7148 (HY-186267).
