Target Protein Ligand-Linker Conjugates
Target Protein Ligand-Linker Conjugate incorporates a ligand for the target protein and a linker. When binding to an E3 ligase ligand, the conjugate will be a PROTAC with ability to induce ubiquitylation and subsequent degradation the protein of interest.
Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases, transcription factors, epigenetic tools and E3 ligase themselves.
The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
All Product Categories
-
Target Protein Ligand-Linker Conjugates Related Products (137)
Related Products (137)
-
CDK9 ligand-Linker Conjugate 1
0 ImagesCat. No.: HY-108375CAS No.: 2118356-95-7CDK9 ligand-Linker Conjugate 1 is a compound formed by conjugation of a selective CDK9 ligand and a PROTAC linker. CDK9 ligand-Linker Conjugate 1 can be further coupled with an E3 ubiquitin ligase ligand to synthesize CDK9 PROTAC (HY-103628). CDK9 ligand-Linker Conjugate 1 is applicable to the research of CDK9-related disease states.
-
Tenovin-3-CO-C9-NH2
0 ImagesCat. No.: HY-182976CAS No.: 2917501-96-1
-
17-Chloro-2,5,8,11-tetraoxaheptadecane
0 ImagesCat. No.: HY-187339CAS No.: 1921097-32-617-Chloro-2,5,8,11-tetraoxaheptadecane is a synthetic intermediate. 17-Chloro-2,5,8,11-tetraoxaheptadecane serves as a precursor to linker alcohol 2-(2-(2-((6-chlorohexyl)oxy)ethoxy)ethoxy)ethan-1-ol for CRBN-recruiting HaloPROTAC preparation.
-
BRD4 ligand 13
0 ImagesCat. No.: HY-178094CAS No.: 1101702-81-1BRD4 ligand 13 is a BRD4 ligand that can be used for the synthesis of PROTACs, such as Cath-L-dBET1 (HY-173257). BRD4 ligand 13 is a target protein ligand-conjugate that can be used for the synthesis of PROTACs, such as SJH1-51B (HY-162240).
-
Target Protein Ligand-Linker Conjugates 2
0 ImagesCat. No.: HY-168693Target Protein Ligand-Linker Conjugates 2 is a conjugate of the Target Protein Ligand and Linker, consisting of Desmethyl-QCA276 (HY-44103) and the corresponding Linker. Target Protein Ligand-Linker Conjugates 2 can be used to synthesize PROTAC BD-9136 (HY-149878).
