Target Protein Ligand-Linker Conjugates
Target Protein Ligand-Linker Conjugate incorporates a ligand for the target protein and a linker. When binding to an E3 ligase ligand, the conjugate will be a PROTAC with ability to induce ubiquitylation and subsequent degradation the protein of interest.
Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases, transcription factors, epigenetic tools and E3 ligase themselves.
The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
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Target Protein Ligand-Linker Conjugates Related Products (138)
Related Products (138)
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mTOR ligand 1-C6-amino
0 ImagesCat. No.: HY-176167CAS No.: 3058330-88-1
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CBP/p300 ligand-Linker Conjugate 3
0 ImagesCat. No.: HY-186064CAS No.: 3102127-04-5
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Desmethyl-QCA276-C3-alkyne
0 ImagesCat. No.: HY-184537CAS No.: 2241294-16-4Desmethyl-QCA276-C3-alkyne (Compound 71) is a Target Protein Ligand-Linker Conjugate, composed of the BET ligand Desmethyl-QCA276 (HY-44103) and the PROTAC linker (HY-W035972). Desmethyl-QCA276-C3-alkyne is applicable for the synthesis of the PROTAC QCA570 (HY-112609). Desmethyl-QCA276-C3-alkyne is used in cancer research.
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N-Descyclopropanecarbaldehyde Olaparib suberic acid
0 ImagesCat. No.: HY-179208CAS No.: 2631575-47-6
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MRTX849 ethoxypropanoic acid
0 ImagesCat. No.: HY-139403CAS No.: 2561529-98-2
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EZH2-IN-13-CO-C9-COOH
0 ImagesCat. No.: HY-187136CAS No.: 3004503-11-8EZH2-IN-13-CO-C9-COOH is a target protein ligand-linker conjugate. EZH2-IN-13-CO-C9-COOH can be used to synthesize PROTAC NUCC-0226272 (HY-157844).
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Tacedinaline-C9-acid
0 ImagesCat. No.: HY-176905Tacedinaline-C9-acid is a HDAC1-3 ligand (HY-50934)-Linker conjugate. Tacedinaline-C9-acid can be used to synthesize HDAC1-3 PROTAC degrader JPS004 (HY-176904).
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3-Fluoro-desmethyl-cabozantinib-C3-O-C3-PEG-acid
0 ImagesCat. No.: HY-176385CAS No.: 2230826-10-33-Fluoro-desmethyl-cabozantinib-C3-O-C3-PEG-acid is a target protein ligand-linker conjugate that incorporates a ligand for c-Met (HY-451241) and a PROTAC linker (HY-W442078), which recruits E3 ligases. 3-Fluoro-desmethyl-cabozantinib-C3-O-C3-PEG-acid can be used in the synthesis of PROTACs, such as SJF-8240 (HY-123961).
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CDK12-Cyclin K Ligand-Linker Conjugates 1
0 ImagesCat. No.: HY-176791CDK12-Cyclin K Ligand-Linker Conjugates 1 is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for CDK12-Cyclin K (HY-176790) and a PROTAC linker (HY-W244922), which recruits E3 ligases. CDK12-Cyclin K Ligand-Linker Conjugates 1 can be used for synthesis of PROTAC PP-C8 (HY-144691).
