Target Protein Ligand-Linker Conjugates
Target Protein Ligand-Linker Conjugate incorporates a ligand for the target protein and a linker. When binding to an E3 ligase ligand, the conjugate will be a PROTAC with ability to induce ubiquitylation and subsequent degradation the protein of interest.
Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases, transcription factors, epigenetic tools and E3 ligase themselves.
The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
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Target Protein Ligand-Linker Conjugates Related Products (138)
Related Products (138)
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CPI-203-PEG1-C3-O-COOH
0 ImagesCat. No.: HY-42429CAS No.: 1997304-12-7CPI-203-PEG1-C3-O-COOH is a conjugate of the BRD4 ligand (HY-78695) and the linker (HY-42427). CPI-203-PEG1-C3-O-COOH can be used for synthesizing PROTAC BRD4 degrader ARV-771 (HY-100972).
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RIPK1 ligand-Linker Conjugate-2
0 ImagesCat. No.: HY-189353RIPK1 ligand-Linker Conjugate-2 is a conjugate of a RIPK1 ligand and a linker, in which the RIPK1 ligand is RIPK1-IN-37 (HY-179235) and the linker is Boc-2,6-Diazaspiro[3.3]heptane-Py-Ph-acid (HY-189354). RIPK1 ligand-Linker Conjugate-2 can be used to synthesize RIPK1 PROTAC degraders, such as LD5095 (HY-189352).
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ER ligand-14-PEG3-Boc
0 ImagesCat. No.: HY-180852ER ligand-14-PEG3-Boc is a conjugate of a target protein ligand and linker, composed of an estrogen receptor ligand and a corresponding linker. ER ligand-14-PEG3-Boc can be used to synthesize PROTACs such as ERB-2 (HY-180850). ERB-2 exhibits good antiproliferative activity against Osimertinib (HY-15772)-resistant non-small cell lung cancer.
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BRD4 ligand-Linker Conjugate 1 TFA
0 ImagesCat. No.: HY-132943APurity: 98.66%
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TEAD ligand-Linker Conjugate 1
0 ImagesCat. No.: HY-186023CAS No.: 2918762-34-0
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PROTAC BRD4 ligand-1-NH-PEG-phenol-PEG-COOtBu
0 ImagesCat. No.: HY-176369CAS No.: 2973054-19-0
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Ahx-DM1 TFA
0 ImagesCat. No.: HY-147050ACAS No.: 1702356-22-6Ahx-DM1 (TFA) (compound 2A) is a conjugate of protein/peptide which can be combined with a therapeutic, diagnostic or labelling agent.
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BRD4 ligand-Linker Conjugate 1
0 ImagesCat. No.: HY-132943CAS No.: 2154358-89-9
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CCR9 ligand-Linker Conjugate 1
0 ImagesCat. No.: HY-181288CAS No.: 2906191-39-5
