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Cat. No.: HY-183719

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M4K2009-CH2-piperidine

M4K2009-CH2-piperidine (Compound 38) is a conjugate of an ALK ligand and a linker, which can be used for the synthesis of PROTACs, such as M4K3233 (HY-183717).

For research use only. We do not sell to patients.

Formula: C₃₁H₄₀N₄O₃
Molecular Weight:516.67

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

M4K2009-CH2-piperidine Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

M4K2009-CH2-piperidine (Compound 38) is a conjugate of an ALK ligand and a linker, which can be used for the synthesis of PROTACs, such as M4K3233 (HY-183717)^[1].

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 516.67
Formula C₃₁H₄₀N₄O₃
SMILES

CC1=C(C2=CC=C(N3CCN(CC4CCNCC4)CC3)C=C2)C=NC=C1C5=CC(OC)=C(OC)C(OC)=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Webb DT, et al. Targeting Activin Receptor-like Kinase 2 Using Heterobifunctional Protein Degraders. Journal of medicinal chemistry. 2026 May 14;69(9):11524-11546. [Content Brief]

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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