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Cat. No.: HY-175627

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HDAC6 ligand-6

HDAC6 ligand-6 is a target protein ligand used for PROTACs. HDAC6 ligand-6 can be used to synthesize the PROTAC PRO-HD1 (HY-155396).

For research use only. We do not sell to patients.

Formula: C₂₀H₁₈ClNOS
Molecular Weight:355.88

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

HDAC6 ligand-6 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

HDAC6 ligand-6 is a target protein ligand used for PROTACs. HDAC6 ligand-6 can be used to synthesize the PROTAC PRO-HD1 (HY-155396)^[1].

IC₅₀ & Target

HDAC6

All HDAC Isoforms :

In Vitro

The ligand for the target protein causes the PROTAC to attach to the target protein, leading to its ubiquitination and subsequent degradation.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 355.88
Formula C₂₀H₁₈ClNOS
SMILES

S=C1N(CC2=CC=C(C3=CC=C(CCl)C=C3)C=C2)C=CC=C1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Qi Jia, et al. Cell-Specific Degradation of Histone Deacetylase Using Warhead-Caged Proteolysis Targeting Chimeras. Analytical Chemistry 2023 95 (45), 16474-16480

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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