2. PROTAC Cell Cycle/DNA Damage Epigenetics
  3. Ligands for Target Protein for PROTAC HDAC
  4. HDAC6-IN-68

HDAC6-IN-68 is an HDAC6 PROTAC ligand. HDAC6-IN-68 can be used to synthesize PROTAC HDAC6 degrader 7 (HY-179421).

For research use only. We do not sell to patients.

HDAC6-IN-68

HDAC6-IN-68 Chemical Structure

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HDAC6-IN-68 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

HDAC6-IN-68 is an HDAC6 PROTAC ligand. HDAC6-IN-68 can be used to synthesize PROTAC HDAC6 degrader 7 (HY-179421)[1].

IC50 & Target

HDAC6

118 nM (IC50)

In Vitro

HDAC6 PROTAC contains two different ligands connected by a linker; one is an E3 ligase ligand (Thalidomide 5-fluoride) (HY-W087383), and the other is for Ligands of HDAC6 target protein (HDAC6-IN-68) (HY-179422). PROTAC exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC6-IN-68 Related Antibodies
Molecular Weight

385.46

Formula

C24H23N3O2
SMILES

O=C(C1=CC=C(CN2C3=CC=CC=C3C=CC4=C2C=CC=C4O)C=C1)NNCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HDAC6-IN-68 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC6-IN-68Ligands for Target Protein for PROTACHDACTarget Protein-binding MoietyHistone deacetylasesPROTACHDAC6 degradersNLRP3 inflammasomeNF-κB signalingUbiquitin-proteasome pathwayInhibitorinhibitorinhibit

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HDAC6-IN-68
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HY-179422
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