2906191-39-5
2906191-39-5
Chemical Structure
CCR9 ligand-Linker Conjugate 1
- CAS No.: 2906191-39-5
- Formula:C28H32ClN5O7S
- Molecular Weight:618.10
InChIKey: FLTFHMAKZIBAGF-UHFFFAOYSA-N
SMILES: O=C(C1=CC(Cl)=CC=C1NS(C2=CC=C(C(C)(C)C)C=C2)(=O)=O)C3=CC(OCCOCCOCCN=[N+]=[N-])=[N+]([O-])C=C3
Biological Activity: CCR9 ligand-Linker Conjugate 1 is a target protein ligand-linker conjugate containing a CCR9 ligand and a PROTAC linker, which recruits E3 ligases. USP7 Ligand-Linker Conjugates 1 can be used to synthesize PROTAC CCR9 Degrader 1 (HY-181287)[1][2].
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CCR9 ligand-Linker Conjugate 1 | CCR9 ligand-Linker Conjugate 1 is a target protein ligand-linker conjugate containing a CCR9 ligand and a PROTAC linker, which recruits E3 ligases. USP7 Ligand-Linker Conjugates 1 can be used to synthesize PROTAC CCR9 Degrader 1 (HY-181287). | |||||||||||||||||||||
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References
- [1]. Huber ME, et al. A Chemical Biology Toolbox Targeting the Intracellular Binding Site of CCR9: Fluorescent Ligands, New Drug Leads and PROTACs. Angew Chem Int Ed Engl. 2022;61(12):e202116782. [Content Brief]
- [2]. Frost A, et al. Allosteric PROTACs: Expanding the Horizon of Targeted Protein Degradation. J Am Chem Soc. 2026;148(3):2823-2837. [Content Brief]
Keywords
