Thyroid Hormone Receptor
THR
Thyroid hormone receptor is a member of the nuclear receptor superfamily that shuttles between the cytosol and nucleus. Thyroid hormone receptors are ligand-dependent transcription factors that mediate the biological activities of thyroid hormone (T3). Thyroid hormone receptors are encoded by two genes, one for TRα and another for TRβ, which encode the major isoforms of TR, including TRα1, TRα2, TRβ1, and TRβ2. The thyroid hormone receptors mediate the pleiotropic activities of the thyroid hormone (T3) in growth, development, and differentiation and in maintaining metabolic homeostasis.
Thyroid hormone receptors are zinc finger transcription factors in the erbA superfamily that bind DNA at specific response element sequences (thyroid hormone response elements, TREs) and activate gene expression in response to thyroid hormone (T3). Thyroid hormone receptors have been shown to bind DNA as monomers, homodimers, or heterodimers with another erbA superfamily member, the retinoid X receptor (RXR).
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Thyroid Hormone Receptor Inhibitors
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Thyroid Hormone Receptor Agonists
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Thyroid Hormone Receptor Antagonists
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Thyroid Hormone Receptor Activators
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Thyroid Hormone Receptor Modulators
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Thyroid Hormone Receptor Controls
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Thyroid Hormone Receptor Ligand
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Thyroid Hormone Receptor Related Products (188)
Related Products (188)
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Antibodies (5)
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THR-β agonist 2 diacetate
0 ImagesCat. No.: HY-143613ATHR-β agonist 2 (Compound 3) diacetate is a selective thyroid hormone receptor β (THRβ) agonist with an EC50 of 1.42 μM. THR-β agonist 2 diacetate can regulate the biological pathways mediated by thyroid hormones. THR-β agonist 2 diacetate can be used for the study of metabolic diseases.
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ITYR-DBRMD
0 ImagesCat. No.: HY-182688CAS No.: 1809339-61-4ITYR-DBRMD is a type III deiodinase (DIO3) inhibitor. ITYR-DBRMD shows antidepressant-like activity and reduces latency to feed in mice. ITYR-DBRMD can be used for the research of depression.
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THR-β agonist 10
0 ImagesCat. No.: HY-175676THR-β agonist 10 is an orally active and selective THR-β agonist, with an EC50 of 11 nM. THR-β agonist 10 significantly reduces ALT (Alanine Aminotransferase), TC (Total Cholesterol), and LDL-C (Low-Density Lipoprotein Cholesterol) levels, and improves steatosis, ballooning, inflammation and fibrosis in the metabolic dysfunction-associated steatohepatitis (MASH) mouse model. THR-β agonist 10 can be used for the study of MASH.
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TRβ agonist 2
0 ImagesCat. No.: HY-147500CAS No.: 2411099-30-2TRβ agonist 2 (Compound 1) is a potent agonist of TRβ. TRβ agonist 2 reduces lipid accumulation in HepG2 and promote lipolysis with comparable effects. TRβ agonist 2 is a new potential TRβ-selective thyromimetics.
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L-Thyroxine sodium (Standard)
0 ImagesSynonyms: Levothyroxine sodium (Standard); T4 sodium (Standard)L-Thyroxine (sodium) (Standard) is the analytical standard of L-Thyroxine (sodium). This product is intended for research and analytical applications. L-Thyroxine sodium (Levothyroxine sodium) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).
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pTH (53-84) (human)
0 ImagesCat. No.: HY-P4700CAS No.: 89439-30-5pTH (53-84) (human) is apTH ((Human parathyroid hormone) fragment.
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THRβ receptor agonist-1
0 ImagesCat. No.: HY-153535CAS No.: 2403721-00-4THRβ receptor agonist-1 is a THRβ receptor agonist.
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MLS000389544
0 ImagesCat. No.: HY-125787CAS No.: 573965-48-7MLS000389544 is a selective and potent methylsulfonylnitrobenzoate thyroid hormone receptor β (TRβ) antagonist that blocks the association of TRβ with steroid receptor coactivator 2 (SRC2).
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Reverse T3-13C6 hydrochloride
0 ImagesCat. No.: HY-W010696ASCAS No.: 1217676-14-6Synonyms: 3′,5′,3-Triiodothyronine-13C6 hydrochlorideReverse T3-13C6 (hydrochloride) is the 13C labeled Reverse T3.
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THR-β modulator-1
0 ImagesCat. No.: HY-153637CAS No.: 2770373-00-5THR-β modulator-1 (compound 1a) is a potent thyroid hormone receptor β modulator. THR-β modulator-1 can be used in research of thyroid hormone receptor related disorders.
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pTH (3-34) (bovine)
0 ImagesCat. No.: HY-P4696CAS No.: 51257-86-4pTH (3-34) (bovine) is apTH ((Human parathyroid hormone) fragment.
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L-Thyroxine-13C6-1
0 ImagesCat. No.: HY-18341S4CAS No.: 1217780-14-7Synonyms: Levothyroxine-13C6-1; T4-13C6-1L-Thyroxine-13C6-1 (Levothyroxine-13C6-1; T4-13C6-1) is a 13C labeled L-Thyroxine (HY-18341). L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).
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JTP 2942
0 ImagesCat. No.: HY-119495CAS No.: 148152-77-6JTP 2942 is a thyrotropin-releasing hormone analogue. JTP 2942 can promote the release of Acetylcholine in the hippocampus and frontal cortex of rats. JTP 2942 possesses neuroprotective and cognitive-improving activities. JTP 2942 dose-dependently improves motor and neurological deficits in rat models of chronic focal cerebral ischemia. JTP 2942 can be used for the research of cerebral ischemia, motor neuron diseases, and other related conditions.
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THR-β agonist 7
0 ImagesCat. No.: HY-160266CAS No.: 2604229-32-3THR-β agonist-1 (Example 2) is a THR-β agonist, with EC50 values of 52 nM and 1017 nM for THR-β and THR-α, respectively.
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MGL-319613C3,15N; VIA-319613C3,15N
0 ImagesCat. No.: HY-12216SSynonyms: MGL-319613C3,15N; VIA-319613C3,15NResmetirom-13C3,15N (MGL-3196-13C3,15N) is the 13C- and 15N-labeled Resmetirom (HY-12216). Resmetirom (MGL-3196) is a highly selective and orally active thyroid hormone receptor β (THR-β) agonist with an EC50 value of 0.21 μM. Resmetirom can be used for the study of noncirrhotic nonalcoholic steatohepatitis.
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Taltirelin-13C,d3
0 ImagesCat. No.: HY-B0596SSynonyms: TA-0910-13C,d3Taltirelin-13C,d3 (TA-0910-13C,d3) is 13C and deuterated labeled Taltirelin (HY-B0596). Taltirelin (TA0910) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release).
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Debutyldronedarone-d7
0 ImagesCat. No.: HY-12753SCAS No.: 2070015-16-4Synonyms: SR35021-d7Debutyldronedarone-d7 (SR35021-d7) is the deuterated-labeled Debutyldronedarone (HY-12753). Debutyldronedarone (SR35021) is a Cytochrome P450 enzyme inhibitor and a Thyroid Hormone Receptor inhibitor, and it is a metabolite of Dronedarone (HY-A0016). Debutyldronedarone inhibits the binding of T3 to TRα1 and TRβ1. Debutyldronedarone reduces the incidence of reperfusion-induced ventricular fibrillation in anesthetized rats, while decreasing their heart rate and blood pressure. Debutyldronedarone can be used in studies related to ventricular fibrillation and atrial fibrillation.
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Iodothiouracil
0 ImagesIodothiouracil exhibits high selectivity for melanoma, remains stable in the melanin in melanoma cells, and localizes remote secondary metastases of melanoma. Iodothiouracil can be used for melanoma imaging when labeled with iodine-123, and can be used for radiation therapy when labeled with iodine-131.
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Human PTH-(1-31)
0 ImagesCat. No.: HY-P4817CAS No.: 157938-23-3Human PTH-(1-31) is the 1-31 fragment of human PTH. Human PTH-(1-31) stimulates the release of cAMP and also is a weaker stimulator of the 25-hydroxyvitamin D-1α-hydroxylase. Human PTH-(1-31) induces bone formation without inducing bone resorption. Human PTH-(1-31) has the potential for the research of osteoporosis.
