Thyroid Hormone Receptor
THR
Thyroid hormone receptor is a member of the nuclear receptor superfamily that shuttles between the cytosol and nucleus. Thyroid hormone receptors are ligand-dependent transcription factors that mediate the biological activities of thyroid hormone (T3). Thyroid hormone receptors are encoded by two genes, one for TRα and another for TRβ, which encode the major isoforms of TR, including TRα1, TRα2, TRβ1, and TRβ2. The thyroid hormone receptors mediate the pleiotropic activities of the thyroid hormone (T3) in growth, development, and differentiation and in maintaining metabolic homeostasis.
Thyroid hormone receptors are zinc finger transcription factors in the erbA superfamily that bind DNA at specific response element sequences (thyroid hormone response elements, TREs) and activate gene expression in response to thyroid hormone (T3). Thyroid hormone receptors have been shown to bind DNA as monomers, homodimers, or heterodimers with another erbA superfamily member, the retinoid X receptor (RXR).
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Thyroid Hormone Receptor Inhibitors
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Thyroid Hormone Receptor Antagonists
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Thyroid Hormone Receptor Activators
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Thyroid Hormone Receptor Modulators
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Thyroid Hormone Receptor Ligand
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Thyroid Hormone Receptor Related Products (188)
Related Products (188)
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Antibodies (5)
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Biotin-(L-Thyroxine)
0 ImagesCat. No.: HY-18341FCAS No.: 149734-00-9Biotin-(L-Thyroxine) is the biotinylated L-Thyroxine (HY-18341). L-Thyroxine is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from Biotin-(L-Thyroxine) (T4).
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Trh-gly
0 ImagesCat. No.: HY-W345393CAS No.: 85344-77-0Synonyms: TRH-glycineTrh-gly (TRH-glycine) is a precursor of thyrotropin (TSH)-releasing hormone (TRH) that can release thyrotropin and prolactin.
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Progoitrin potassium
0 ImagesCat. No.: HY-N10348ACAS No.: 21087-77-4Progoitrin potassium is an orally active glucosinolate. As the precursor of goitrin (HY-N0224A), an antithyroid compound, progoitrin releases goitrin via hydrolysis by myrosinase or gastrointestinal glucosidase. Progoitrin converts to goitrin in vivo and exerts antithyroid activity by inhibiting the accumulation of radioactive iodine in the thyroid gland. Progoitrin potassium can be used in the research of Graves' disease (thyrotoxicosis).
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Thyroxine hydrochloride-13C6
0 ImagesCat. No.: HY-18341S1CAS No.: 1421769-38-1Synonyms: Levothyroxine-13C6; T4-13C6Thyroxine hydrochloride-13C6 is the 13C-labeled L-Thyroxine. L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).
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[Phe2]-TRH
![[Phe2]-TRH](https://file.medchemexpress.com/product_pic/hy-p3962.gif "Click to View [Phe2]-TRH Product Detail")
0 ImagesCat. No.: HY-P3962CAS No.: 34783-35-2[Phe2]-TRH is a thyrotropin releasing hormone analogue, equipping a conformational similarity with Leu5-enkephalin.
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Encaleret sodium
0 ImagesCat. No.: HY-14401BCAS No.: 787584-62-7Synonyms: CLTX-305 sodium; JTT-305 sodium; MK-5442 sodiumEncaleret (CLTX-305) sodium is an orally active antagonist of the calcium-sensing receptor (CaSR), with an IC50 of 12 nM. Encaleret sodium exerts its effect by inhibiting the excessive activity of functional gain-of-function CaSR variants, and can restore blood calcium levels, promote the secretion of parathyroid hormone, improve magnesium and phosphorus metabolism, and increase urinary calcium excretion. Encaleret sodium can be used in the research of diseases such as osteoporosis and autosomal dominant hypocalcemia type 1.
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1α-Hydroxy-3-epi-vitamin D3
0 Images1α-Hydroxy-3-epi-vitamin D3, a natural metabolite of 1alpha,25-dihydroxyvitamin D3, is a potent suppressor of parathyroid hormone (PTH) secretion.
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Kylo-0603
0 ImagesCat. No.: HY-172661CAS No.: 2661053-09-2Kylo-0603 is an orally active thyroid hormone receptor β (THR-β) agonist with an EC50 of 31.07 nM against human targets, and it exhibits much higher selectivity for THR-β than for THR-α. Kylo-0603 enables hepatocyte-targeted delivery via GalNAc modification. Kylo-0603 reduces serum cholesterol and low-density lipoprotein cholesterol levels. Kylo-0603 alleviates hepatic steatosis, inflammatory responses, hepatocyte ballooning, and non-alcoholic steatohepatitis activity scores. Kylo-0603 inhibits the progression of hepatic fibrosis. Kylo-0603 can be used for research on metabolic dysfunction-associated steatohepatitis (MASH).
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N-Acetylthyroxine
0 ImagesCat. No.: HY-117475CAS No.: 26041-51-0N-Acetylthyroxine is a thyroid hormone analogue. N-Acetylthyroxine weakly binds to thyroxine-binding globulin (TBG) in isolated human serum.
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Posatirelin
0 ImagesCat. No.: HY-136800CAS No.: 78664-73-0Posatirelin, a TRH analog, increases monoamine metabolites in the cerebral cortex, nucleus accumbens, and striatum, and possibly exerts CNS activating effects through a modification of several neurotransmitter systems.
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MB-07811 (Standard)
0 ImagesCat. No.: HY-111288RCAS No.: 852948-13-1Synonyms: VK-2809 (Standard)MB-07811 (Standard) is the analytical standard of MB-07811 (HY-111288). This product is intended for research and analytical applications. MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB07344, a liver-targeted thyroid hormone receptor-β agonist. MB-07811 has cholesterol and triglycerides lowering activity.
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Eprotirome (Standard)
0 ImagesSynonyms: KB2115 (Standard)Eprotirome (Standard) is the analytical standard of Eprotirome (HY-10473). This product is intended for research and analytical applications. Eprotirome (KB2115) is a liver-selective thyroid hormone receptor (TR) agonist. KB2115 has modestly higher affinity for TRβ than for TRα. Eprotirome reduces low-density lipoprotein (LDL) cholesterol concentrations. Eprotirome can be used for dyslipidemias and obesity research.
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Orotirelin
0 ImagesCat. No.: HY-122353CAS No.: 62305-86-6Synonyms: CG 3509Orotirelin (CG 3509) is a thyrotrophin-releasing hormone (TRH) analogue. Orotirelin can be used in the study of neurological diseases.
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Propylthiouracil (Standard)
0 ImagesSynonyms: 6-n-Propylthiouracil (Standard); 6-Propyl-2-thiouracil (Standard); PTU (Standard)Propylthiouracil (Standard) is the analytical standard of Propylthiouracil. This product is intended for research and analytical applications. Propylthiouracil (6-n-Propylthiouracil), a thioamide antithyroid agent, is an orally active thyroperoxidase and type-1 deiodinase (DIO1) inhibitor. Propylthiouracil can be used for the Graves disease and hyperthyroidism research.
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Liothyronine-d3
0 ImagesCat. No.: HY-A0070AS3Synonyms: Triiodothyronine-d3; 3,3',5-Triiodo-L-thyronine-d3; T3-d3Liothyronine-d3 is deuterated labeled Liothyronine (HY-A0070A). Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively.
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TRβ agonist-4
0 ImagesCat. No.: HY-182769CAS No.: 3066979-01-6TRβ agonist-4 is an orally bioavailable, liver-targeted selective agonist of hTHR-β (EC50=6.0 nM), with a 105.3-fold selectivity over THR-α. TRβ agonist-4 exists in multiple crystal forms, including Form A, Form B, Form C, Form D, Form E, as well as an amorphous form. TRβ agonist-4 can be used for research related to non-alcoholic steatohepatitis (NASH).
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THRβ receptor agonist-2
0 ImagesCat. No.: HY-174805CAS No.: 2411677-11-5THRβ receptor agonist-2 (Example 7-4) is a THRβ receptor agonist. THRβ receptor agonist-2 can be used for research of liver disorder or a cardiometabolic disease.
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Octinoxate-13C,d3
0 ImagesCat. No.: HY-B1234SOctinoxate-13C,d3 is the deuterium labeled Octinoxate (HY-W245806). Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo.
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TR antagonist 1 (Standard)
0 ImagesCat. No.: HY-111443RCAS No.: 500794-88-7TR antagonist 1 (Standard) is the analytical standard of TR antagonist 1 (HY-111443). This product is intended for research and analytical applications. TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC50s of 36 and 22 nM for TRα and TRβ, respectively.
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Tiratricol (Standard)
0 ImagesTiratricol (Standard) is the analytical standard of Tiratricol. This product is intended for research and analytical applications. Tiratricol is an orally available thyroid hormone analog that inhibits pituitary thyroid-stimulating hormone secretion. Tiratricol is an intracellular toxin neutralizer that inhibits LPS and lipid A cytotoxicity with IC50s of 20 μM and 32 μM, respectively. Tiratricol reduces TNF production in lipopolysaccharide-stimulated macrophages. Tiratricol also has antiviral activity and is an inhibitor of yellow fever virus (Flavivirus). It can bind to the RdRp domain of the viral NS5 protein to hinder YFV replication..
