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Cat. No.: HY-111443R

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TR antagonist 1 (Standard)

TR antagonist 1 (Standard) is the analytical standard of TR antagonist 1 (HY-111443). This product is intended for research and analytical applications. TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC₅₀s of 36 and 22 nM for TRα and TRβ, respectively.

For research use only. We do not sell to patients.

CAS No.: 500794-88-7
Formula: C₂₅H₂₃Br₂NO₄
Molecular Weight:561.26

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

TR antagonist 1 (Standard) Chemical Structure

CAS No.: 500794-88-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 500794-88-7
Molecular Weight 561.26
Formula C₂₅H₂₃Br₂NO₄
SMILES

O=C(O)CCC1=CC(Br)=C(OC2=CC(/C=C/C3=CC=NC=C3)=C(O)C(C(C)C)=C2)C(Br)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Koehler K, et al. Thyroid receptor ligands. 6. A high affinity "direct antagonist" selective for the thyroid hormone receptor. J Med Chem. 2006 Nov 16;49(23):6635-7. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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