Thyroid Hormone Receptor
THR
Thyroid hormone receptor is a member of the nuclear receptor superfamily that shuttles between the cytosol and nucleus. Thyroid hormone receptors are ligand-dependent transcription factors that mediate the biological activities of thyroid hormone (T3). Thyroid hormone receptors are encoded by two genes, one for TRα and another for TRβ, which encode the major isoforms of TR, including TRα1, TRα2, TRβ1, and TRβ2. The thyroid hormone receptors mediate the pleiotropic activities of the thyroid hormone (T3) in growth, development, and differentiation and in maintaining metabolic homeostasis.
Thyroid hormone receptors are zinc finger transcription factors in the erbA superfamily that bind DNA at specific response element sequences (thyroid hormone response elements, TREs) and activate gene expression in response to thyroid hormone (T3). Thyroid hormone receptors have been shown to bind DNA as monomers, homodimers, or heterodimers with another erbA superfamily member, the retinoid X receptor (RXR).
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Thyroid Hormone Receptor Inhibitors
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Thyroid Hormone Receptor Antagonists
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Thyroid Hormone Receptor Modulators
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Thyroid Hormone Receptor Ligand
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Thyroid Hormone Receptor Related Products (188)
Related Products (188)
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Antibodies (5)
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THR-β agonist 12
0 ImagesCat. No.: HY-184939CAS No.: 3063509-17-8THR-β agonist 12 is an orally active, potent, and highly selective thyroid hormone receptor β (THR-β) agonist (EC50 = 36 nM). THR-β agonist 12 shows no significant activity against THRα and exhibits no cardiotoxicity in vivo. THR-β agonist 12 inhibits lipid synthesis by activating the AMPK-ACC-SREBP1 signaling axis. THR-β agonist 12 can be used on research into metabolic dysfunction-associated steatohepatitis (MASH) and related metabolic diseases.
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Debutyldronedarone hydrochloride (Standard)
0 ImagesCat. No.: HY-12753ARCAS No.: 197431-02-0Synonyms: SR35021 hydrochloride (Standard)Debutyldronedarone hydrochloride (Standard) (SR35021 hydrochloride (Standard)) is the analytical standard of Debutyldronedarone (hydrochloride) (HY-12753A). This product is intended for research and analytical applications. Debutyldronedarone hydrochloride (SR35021 hydrochloride) is a Cytochrome P450 enzyme inhibitor and a Thyroid Hormone Receptor inhibitor, and it is a metabolite of Dronedarone (HY-A0016). Debutyldronedarone hydrochloride inhibits the binding of T3 to TRα1 and TRβ1. Debutyldronedarone hydrochloride reduces the incidence of reperfusion-induced ventricular fibrillation in anesthetized rats, while decreasing their heart rate and blood pressure. Debutyldronedarone hydrochloride can be used in studies related to ventricular fibrillation and atrial fibrillation.
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Bovine Thyrotropin
0 ImagesBovine Thyrotropin is a pituitary glycoprotein hormone derived from cattle, with identical properties to thyroid-stimulating hormone (TSH). Bovine Thyrotropin stimulates thyroid function and is used to differentiate between primary and secondary hypothyroidism. Bovine Thyrotropin can induce increased radioactive iodine uptake in metastatic thyroid cancer lesions, and long-term administration leads to the production of neutralizing antibodies and hemagglutinating antibodies. Bovine Thyrotropin is applicable to research related to metastatic thyroid cancer.
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L-6424
0 ImagesCat. No.: HY-120358CAS No.: 147030-50-0L-6424 inhibits T3 binding to α1-T3R and β1-T3R.
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Acetiromate
0 ImagesAcetiromate is a thyroxine analogue. Acetiromate is an antilipidemic drug for hyperlipidemia.
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Teriparatide-d10
0 ImagesCat. No.: HY-P0059SSynonyms: Human parathyroid hormone-(1-34)-d10; hPTH (1-34)-d10Teriparatide-d10 (Human parathyroid hormone-(1-34)-d10) is the deuterium labeled Teriparatide (HY-P0059). Teriparatide (Human parathyroid hormone-(1-34)) is a PTH1 receptor agonist. Teriparatide (Human parathyroid hormone-(1-34)) can be used for osteoporosis research.
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Liothyronine-d4
0 ImagesCat. No.: HY-A0070AS5Synonyms: Triiodothyronine-d4; 3,3',5-Triiodo-L-thyronine-d4; T3-d4Liothyronine-d4 (Triiodothyronine-d4) is the deuterium labeled Liothyronine (HY-A0070A). Liothyronine is an active form of thyroid hormone. Liothyronine binds to thyroid hormone receptors TRα and TRβ with vs of 2.33 and 2.29 nM for hTRα and hTRβ, respectively. Liothyronine also binds to PVR and blocks the interaction of TIGIT/PVR.
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Osteostatin (human)
0 ImagesCat. No.: HY-P4800CAS No.: 137348-10-8Synonyms: Human PTHrP(107-139)Osteostatin (human), a fragment of parathyroid hormone-related protein (PTHrP) 107-139, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis.
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TA 0910 acid-type
0 ImagesTA 0910 acid-type is a metabolite of TA 0910. TA-0910 is a metabolically stable analogue of thyrotropin releasing hormone (TRH).
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PF-00277343
0 ImagesCat. No.: HY-118978CAS No.: 332926-04-2PF-00277343 is a selective and skin-penetrable THR-β (Ki: 0.51 nM for THR-β, 8.0 nM for THR-α) agonist. PF-00277343 is effective against androgenetic alopecia in animal models.
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D-Thyroxine sodium
0 ImagesD-thyroxine (D-T4) sodium is an orally active thyroid hormone that inhibits the secretion of TSH. D-thyroxine sodium can inhibit goiter, promote metamorphosis of tadpoles and influence cholesterol metabolism. D-thyroxine sodium can be used for the study of hypercholesterolemia.
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Thyroid hormone receptor beta agonist-1
0 ImagesCat. No.: HY-153477CAS No.: 2140902-80-1Thyroid hormone receptor beta agonist-1 (compound 3) is a thyroid beta-agonist.
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ZG-2585
0 ImagesCat. No.: HY-187505CAS No.: 3052796-86-5ZG-2585 is an orally active and selective thyroid hormone receptor β (THRβ) agonist. ZG-2585 selectively activates THRβ over THRα, driving allosteric conformational changes and coactivator recruitment. ZG-2585 reduces body weight, hepatic steatosis and lipid accumulation in a Western diet-induced metabolic disorder model. ZG-2585 can be used for the research of metabolic disorders, including obesity, dyslipidemia and metabolic dysfunction-associated steatohepatitis.
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Sobetirome (GMP)
0 ImagesCat. No.: HY-14823GCAS No.: 211110-63-3Synonyms: GC-1 (GMP); QRX-431 (GMP)Sobetirome (GMP) is Sobetirome (HY-14823) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Sobetirome (GC-1) is a thyroid hormone receptor β (TRβ)-specific agonist which bind selectively to TRβ-1 with an EC50 of 0.16 μM.
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THR-β agonist 4
0 ImagesCat. No.: HY-142917CAS No.: 2673409-25-9THR-β agonist 4 is a potent agonist of THR-β. THR-β agonist 4 has the potential for the research of metabolic diseases such as obesity, hyperlipidemia, hypercholesterolemia, diabetes and other conditions such as steatosis and non-alcoholic steatohepatitis (NASH), atherosclerosis and other related conditions and diseases (extracted from patent WO2021143706A1, compound 72).
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A 274
0 ImagesCat. No.: HY-116701CAS No.: 77273-75-7A 274 is an amiodarone analogue that has the activity of inhibiting the binding of T3 to α1- and β1-thyroid hormone receptors in vitro. Its IC50 values for inhibition of α1-T3R and β1-T3R are certain values (depending on the specific experimental results).
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KB-141
0 ImagesCat. No.: HY-117167CAS No.: 219691-94-8KB-141 is a potent and selective TRβ agonist. The IC50 values are 23.9 nM and 3.3 nM for binding affinities from displacement of T3 from hTRα1 and hTRβ1, respectively. KB-141 has anti-obesity, anti-diabetic, and lipid-lowering effects?and can be used as an anti-cholesteremic agent in vivo.
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Rovatirelin
0 ImagesCat. No.: HY-118117CAS No.: 204386-76-5Synonyms: S0373Rovatirelin is an orally active thyrotropin-releasing hormone (TRH) analog. Rovatirelin binds to the human TRH receptor with a Ki value of 702 nM. Rovatirelin can be used to study spinocerebellar degeneration (SCD) .
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LL-340001
0 ImagesCat. No.: HY-187702CAS No.: 2046137-49-7LL-340001 is the receptor-active metabolite released after hydrolysis of Elunetirom (HY-160207) by FAAH in the central nervous system. LL-340001 acts as a thyroid hormone receptor (TR) agonist, with potent full agonist activity at both TRα and TRβ. LL-340001 exhibits neuronal plasticity activity and can activate programs related to neuroplasticity and mitochondrial biogenesis in neuronal systems. LL-340001 can be used in the research of major depressive disorder and bipolar depression.
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ABX-10241
0 ImagesCat. No.: HY-P991361Synonyms: ABX-PTHABX-10241 (ABX-PTH) is a human monoclonal antibody (mAb) targeting Parathyrin. ABX-10241 can be used in Hyperparathyroidism research.
