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Cat. No.: HY-187702

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LL-340001

LL-340001 is the receptor-active metabolite released after hydrolysis of Elunetirom (HY-160207) by FAAH in the central nervous system. LL-340001 acts as a thyroid hormone receptor (TR) agonist, with potent full agonist activity at both TRα and TRβ. LL-340001 exhibits neuronal plasticity activity and can activate programs related to neuroplasticity and mitochondrial biogenesis in neuronal systems. LL-340001 can be used in the research of major depressive disorder and bipolar depression.

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CAS No.: 2046137-49-7
Formule: C₁₈H₁₈Cl₂O₄
Masse moléculaire:369.24

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Please store the product under the recommended conditions in the Certificate of Analysis.

LL-340001 Chemical Structure

CAS No.: 2046137-49-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
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- In Vitro
Chemical Information
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Activité biologique

Description

In Vitro

Aβ/Tau/α-Synuclein AggregationMitochondrial FunctionOthers

Aβ/Tau/α-Synuclein Aggregation

LL-340001 (1 nM-1 μM, 28 h) maintains the number of synapses in mature primary rat hippocampal neurons under pathological stress induced by Aβ_1-42, and exhibits potent activity within the low nanomolar range^[1].

Mitochondrial Function

LL-340001 (0.3-3 nM; 72 h) enhances signaling pathways associated with mitochondrial biogenesis (upregulates nuclear PGC-1α and NRF2 expression), increases the number of functional mitochondria, and elevates ATP levels in mature primary rat hippocampal neurons within 72 h, exhibiting potent activity in the low nanomolar range^[1].

Others

LL-340001 (administered for 23 h) potently activates TRα and TRβ receptors in HEK293-derived reporter cells^[1].
LL-340001 (1-30 nM, 3 μM; 72 h) increases the number of MAP-2-positive neurons, neurite length, number of branches, and number of neurite terminals in primary cortical neurons from immature rats within 72 hours, and exhibits potent activity in the low nanomolar range^[1].
The increase in the number of MAP-2-positive neurons induced by LL-340001 (3-30 nM; 73 h) in immature primary rat cortical neurons is sensitive to TrkB inhibition but independent of the 5-HT2A signaling pathway, whereas its neuritogenic effect is not consistently sensitive to TrkB antagonism^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Endocrine Diseases

Chemical Information

CAS No. 2046137-49-7
Masse moléculaire 369.24
Formule C₁₈H₁₈Cl₂O₄
SMILES

CC(C)C1=C(O)C=CC(CC2=C(Cl)C=C(OCC(O)=O)C=C2Cl)=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Harris JR, et al. Elunetirom, a brain-targeted TRβ prodrug, promotes neuronal plasticity and mitochondrial biogenesis-related signaling in primary neuronal cultures. bioRxiv. 2026:2026-07.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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