LL-340001

LL-340001 (administered for 23 h) potently activates TRα and TRβ receptors in HEK293-derived reporter cells^[1].
LL-340001 (1-30 nM, 3 μM; 72 h) increases the number of MAP-2-positive neurons, neurite length, number of branches, and number of neurite terminals in primary cortical neurons from immature rats within 72 hours, and exhibits potent activity in the low nanomolar range^[1].
The increase in the number of MAP-2-positive neurons induced by LL-340001 (3-30 nM; 73 h) in immature primary rat cortical neurons is sensitive to TrkB inhibition but independent of the 5-HT2A signaling pathway, whereas its neuritogenic effect is not consistently sensitive to TrkB antagonism^[1].
LL-340001 (1 nM-1 μM, 28 h) maintains the number of synapses in mature primary rat hippocampal neurons under pathological stress induced by Aβ_1-42, and exhibits potent activity within the low nanomolar range^[1].
LL-340001 (0.3-3 nM; 72 h) enhances signaling pathways associated with mitochondrial biogenesis (upregulates nuclear PGC-1α and NRF2 expression), increases the number of functional mitochondria, and elevates ATP levels in mature primary rat hippocampal neurons within 72 h, exhibiting potent activity in the low nanomolar range^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.