2. Vitamin D Related/Nuclear Receptor
  3. Thyroid Hormone Receptor
  4. ITYR-DBRMD

ITYR-DBRMD is a type III deiodinase (DIO3) inhibitor. ITYR-DBRMD shows antidepressant-like activity and reduces latency to feed in mice. ITYR-DBRMD can be used for the research of depression.

For research use only. We do not sell to patients.

ITYR-DBRMD

ITYR-DBRMD Chemical Structure

CAS No. : 1809339-61-4

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ITYR-DBRMD Related Antibodies

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Description

ITYR-DBRMD is a type III deiodinase (DIO3) inhibitor. ITYR-DBRMD shows antidepressant-like activity and reduces latency to feed in mice. ITYR-DBRMD can be used for the research of depression[1].

In Vitro

ITYR-DBRMD (Compouund 5) (0.5 μM; 48 h) reduces cell viability in OVCAR3 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ITYR-DBRMD Related Antibodies

Cell Viability Assay[1]

Cell Line: OVCAR3 cells
Concentration: 0.5 μM
Incubation Time: 48 h
Result: Reduced cell numbers by microscopy.
In Vivo

ITYR-DBRMD (Compound 5) (5 mg/kg; i.c.v.; continuous infusion via osmotic minipump) reduces the latency to feed in the novelty suppressed feeding test in BALB/c mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (male, 8 weeks old)[1]
Dosage: 5 mg/kg
Administration: i.c.v.; continuous infusion via osmotic minipump
Result: Reduced the latency to feed in the novelty suppressed feeding test.
Molecular Weight

670.82

Formula

C13H7Br2I2NO5
CAS No.
SMILES

O=C(C(CC1=CC(I)=C(C(I)=C1)O)N2C(C(Br)=C(C2=O)Br)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ITYR-DBRMD Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ITYR-DBRMD1809339-61-4Thyroid Hormone ReceptorTHRType III deiodinaseBALB/c miceT3T2depressiondiiodothyroninetriiodothyroninemiceDIO3novelty suppressed feeding testInhibitorinhibitorinhibit

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