2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Tyrosinase

Tyrosinase

Tyrosinase

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Tyrosinase is a copper-containing metalloprotein belonging to the type-3 copper protein family, together with haemocyanins and catechol oxidases. Tyrosinases are the catalysts in mammals responsible for the formation of melanin in skin and hair color, as well as browning in fruit and vegetables following cell damage.

Tyrosinases are found in various prokaryotes as well as in plants, fungi, arthropods, and mammals and are responsible for pigmentation, wound healing, radiation protection, and primary immune response. Tyrosinases perform two sequential enzymatic reactions: hydroxylation of monophenols and oxidation of diphenols to form quinones which polymerize spontaneously to melanin. In plants, sponges, and many invertebrates, tyrosinases are important for wound healing and primary immune responses; in arthropods, they play a role in sclerotization, and in bacteria, tyrosinases protect DNA from UV damage.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-159586
    Tyrosinase-IN-32
    		Inhibitor
    Tyrosinase-IN-32 (compound 11) is a hydroxamate-based alkaloid and a mushroom tyrosinase inhibitor. Tyrosinase-IN-32 has antioxidant activity and can be isolated from black pepper (Piper nigrum L.).
    Tyrosinase-IN-32
  • HY-157010
    AP736
    		Inhibitor
    AP736 is a potent tyrosinase inhibitor (IC50 = 0.9 μM) with anti-melanogenesis activity in normal human melanocytes (IC50 = 0.11 μM). AP736 suppresses the expression of tyrosinase and TRP-1/2 by inhibiting the cAMP-PKA-CREB signalling axis, leading to reduced microphthalmia-associated transcription factor (MITF) transcripts and proteins. AP736 can be used for melanogenesis and hyperpigmentation research.
    AP736
  • HY-Y0444R
    D-Tyrosine (Standard)
    		Inhibitor
    D-Tyrosine (Standard) is the analytical standard of D-Tyrosine (HY-Y0444). This product is intended for research and analytical applications. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth.
    D-Tyrosine (Standard)
  • HY-173512
    mTYR-IN-1
    		Inhibitor
    mTYR-IN-1 (compound 3e) is a reversible and competitive mTYR inhibitor with an IC50 of 4.86 μM. mTYR-IN-1 can be used in the study of skin pigmentation.
    mTYR-IN-1
  • HY-W097858
    2-Hydroxy-4-methoxybenzoic acid potassium
    		Inhibitor 99.96%
    2-Hydroxy-4-methoxybenzoic acid (potassium), is one of the major phytoconstituents of Decalepis arayalpathra, also known as 4-Methoxysalicylic acid (potassium), has a variety of biological effects, including anti-inflammatory, antipyretic, antioxidant, and anti-diabetic properties.
    2-Hydroxy-4-methoxybenzoic acid potassium
  • HY-N7135R
    Tropolone (Standard)
    		Inhibitor
    Tropolone is a seven-membered non-benzenoid aromatic compound, which is the precursor of many Azulene derivatives. Tropolone is a potent mushroom tyrosinase inhibitor with an IC50 value of 0.4 μM. Its inhibitory effect can be achieved by dialysis or excess CU2+ Reversa. Tropolone exhibits broad anti-viral and anti-fungal activity and is synergistic upon co-treatment with nucleos(t)ide analog drugs. Tropolone is a promising candidate for research in osteosarcoma.
    Tropolone (Standard)
  • HY-175377
    (-)-2-Fluorodeoxyarbutin
    		Inhibitor
    (-)-2-Fluorodeoxyarbutin is a fluorinated derivative of the tyrosinase inhibitor deoxyarbutin.
    (-)-2-Fluorodeoxyarbutin
  • HY-113068R
    (rel)-β-Tocopherol (Standard)
    		Inhibitor
    (rel)-β-Tocopherol (Standard) is the analytical standard of (rel)-β-Tocopherol. This product is intended for research and analytical applications. (rel)-β-Tocopherol is a relative configuration of β-Tocopherol.(±)-β-Tocopherol is a lipid-soluble form of vitamin E with antioxidant activity. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol.
    (rel)-β-Tocopherol (Standard)
  • HY-121889
    FQ
    		Inhibitor
    FQ is a tyrosinase inhibitor that effectively inhibits the diphenolase activity of mushroom tyrosinase (IC50=120 μM). FQ can be used in the study of pigmentation.
    FQ
  • HY-N1481R
    Methyl linoleate (Standard)
    		Inhibitor
    Methyl linoleate (Standard) is the analytical standard of Methyl linoleate. This product is intended for research and analytical applications. Methyl linoleate, a major active constituent of Sageretia thea fruit (HFSF), is a major anti-melanogenic compound. Methyl linoleate downregulates microphthalmia-associated transcription factor (MITF) and tyrosinase-related proteins.
    Methyl linoleate (Standard)
  • HY-163734
    Tyrosinase-IN-30
    		Inhibitor
    Tyrosinase-IN-30 (compound 11c) is a potent tyrosinase inhibitor with an IC50 value of 4.52 µM. Tyrosinase-IN-30 shows anti-bacterial activity.
    Tyrosinase-IN-30
  • HY-W013636BR
    Calcium 2-oxoglutarate (Standard)
    		Inhibitor
    Calcium 2-oxoglutarate (Standard) is the analytical standard of Calcium 2-oxoglutarate (HY-W013636B). This product is intended for research and analytical applications. Calcium 2-oxoglutarate is an intermediate in the production of ATP or GTP in the Krebs cycle. Calcium 2-oxoglutarate also acts as the major carbon skeleton for nitrogen-assimilatory reactions. Calcium 2-oxoglutarate is a reversible inhibitor of tyrosinase (IC50=15 mM).
    Calcium 2-oxoglutarate (Standard)
  • HY-N1430R
    Oxyresveratrol (Standard)
    		Inhibitor
    Oxyresveratrol (Standard) is the analytical standard of Oxyresveratrol. This product is intended for research and analytical applications. Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC50 of 28.9 μM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive tyrosinase inhibitor with an IC50 value of 1.2 μM for mushroom tyrosinase. Oxyresveratrol is effective against HSV-1, HSV-2 and varicella-zoster virus, and has neuroprotective effects.
    Oxyresveratrol (Standard)
  • HY-162029
    Tyrosinase-IN-20
    		Inhibitor
    Tyrosinase-IN-20 (compound 6a) is a potent inhibitor of Tyrosinase with an IC50 of 28.50 μM.
    Tyrosinase-IN-20
  • HY-182713
    Tyrphostin AG-808
    		Inhibitor
    Tyrphostin AG-808 is a protein tyrosine kinase inhibitor that does not reduce neointimal formation. Perivascular implantation of Tyrphostin AG-808 causes medial damage in rats.
    Tyrphostin AG-808
  • HY-N1386R
    2-Methoxycinnamic acid (Standard)
    		Inhibitor
    2-Methoxycinnamic acid is a noncompetitive inhibitor of tyrosinase.
    2-Methoxycinnamic acid (Standard)
  • HY-W552702
    Tyrosinase-IN-29
    		Inhibitor
    Tyrosinase-IN-29 (compound 5c) is a potent inhibitor of tyrosinase abTYR (IC50: 6.11 μM). Tyrosinase-IN-29 can be used to further study the inhibition of skin hyperpigmentation.
    Tyrosinase-IN-29
  • HY-121174
    Alaternin
    		Inhibitor
    Alaternin (Catharticin) is an anthraquinone compound with antioxidant and hepatoprotective activities. Alaternin has an inhibitory activity against hydroxyl radicals generated in a cell-free chemical system (FeSO4/H2O2) with an IC50 value of 3.05 μM. Alaternin exhibits hepatoprotective activity against Tacrine (HY-111338)-induced toxicity in human hepatic HepG2 cells with an EC50 value of 4.02 μM.
    Alaternin
  • HY-175349
    Tyrosinase-IN-43
    		Inhibitor
    Tyrosinase-IN-43 (Compound 12j) is a competitive Tyrosinase inhibitor with an IC50 of 10.49 ?μM for tyrosinase. Tyrosinase-IN-43 has significant antioxidant activity. Tyrosinase-IN-43 can be used for hyperpigmentation-related complications such as melasma, freckles, age spots and post-inflammatory hyperpigmentation research.
    Tyrosinase-IN-43
  • HY-175149A
    (+)-2-Fluorodeoxyarbutin
    		Inhibitor
    (+)-2-Fluorodeoxyarbutin is a fluorinated derivative of the tyrosinase inhibitor deoxyarbutin (HY-B1461).
    (+)-2-Fluorodeoxyarbutin
Cat. No. Product Name / Synonyms Application Reactivity