Tyrosinase
Tyrosinase is a copper-containing metalloprotein belonging to the type-3 copper protein family, together with haemocyanins and catechol oxidases. Tyrosinases are the catalysts in mammals responsible for the formation of melanin in skin and hair color, as well as browning in fruit and vegetables following cell damage.
Tyrosinases are found in various prokaryotes as well as in plants, fungi, arthropods, and mammals and are responsible for pigmentation, wound healing, radiation protection, and primary immune response. Tyrosinases perform two sequential enzymatic reactions: hydroxylation of monophenols and oxidation of diphenols to form quinones which polymerize spontaneously to melanin. In plants, sponges, and many invertebrates, tyrosinases are important for wound healing and primary immune responses; in arthropods, they play a role in sclerotization, and in bacteria, tyrosinases protect DNA from UV damage.
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Tyrosinase Inhibitors
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Tyrosinase Antagonist
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Tyrosinase Activators
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Tyrosinase Modulator
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Tyrosinase Inducer
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Tyrosinase Degrader
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Tyrosinase Substrates
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Tyrosinase Ligand
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Tyrosinase Related Products (320)
Related Products (320)
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Antibodies (9)
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Dihydroaltenuene B
0 ImagesCat. No.: HY-N10219CAS No.: 887751-89-5Dihydroaltenuene B is a potent mushroom tyrosinase inhibitor with an IC50 of 38.33 µM. Dihydroaltenuene B shows the hydrogen bonding interactions between the 3-OH and 4’-OH and the His244, Met280 and Gly281 residues of tyrosinase.
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CGP-59326
0 ImagesCat. No.: HY-117852CAS No.: 173458-56-5Synonyms: TRX-13
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4-Isopropylcatechol
0 Images4-Isopropylcatechol is a potent and irreversible cutaneous depigmenting agent. 4-Isopropylcatechol significantly inhibits protein biosynthesis in mouse melanoma cells containing high levels of tyrosinase. 4-Isopropylcatechol can be use to study hyperpigmentation of skins.
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Ailancoumarin E
0 ImagesCat. No.: HY-N12875Ailancoumarin E (Compound 5) is a derivative of Coumarin (HY-N0709). Ailancoumarin E exhibits antifeedant activity toward Plutella xylostella, and inhibits growth of third instar larva. Ailancoumarin E inhibits tyrosinase with IC50 of 14.21 μM.
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Phaeosphaone D
0 ImagesCat. No.: HY-N10285CAS No.: 2640137-78-4Phaeosphaone D is a thiodiketopiperazine alkaloid compound isolated from Phaeosphaeria fuckelii, an endophytic fungus. Phaeosphaone D displays mushroom tyrosinase inhibitory activity with an IC50 value of 33.2 μM.
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Tyrosinase-IN-48
0 ImagesCat. No.: HY-181028Tyrosinase-IN-48 (Compound 3) is a potent and competitive chalcone-based tyrosinase inhibitor with an IC50 of 0.49 μM. Tyrosinase-IN-48 has potent antioxidant potential with significant DPPH and ABTS radical scavenging capacity. Tyrosinase-IN-48 can chelate the binuclear copper ions in the active center of tyrosinase and reduce Cu2+ to Cu+, thereby reducing the catalytic activity of the enzyme. Tyrosinase-IN-48 has low cytotoxicity for HEK293 cells and zebrafish embryo. Tyrosinase-IN-48 shows antibrowning effects to improve food quality and can be used for research of food preservation.
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Tyrosinase-IN-21
0 ImagesCat. No.: HY-162140Tyrosinase-in-21 (compound 3g) is a tyrosinase inhibitor with IC50 value of 80.93 μM.
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Steppogenin 7-O-β-D-glucoside
0 ImagesCat. No.: HY-N21977CAS No.: 20194-60-9Synonyms: StepposideSteppogenin 7-O-β-D-glucoside (Stepposide) is a natural flavanone glycoside and tyrosinase (Tyrosinase) inhibitor, with an IC50 of 5.99 μM against mushroom tyrosinase. Steppogenin 7-O-β-D-glucoside is found in the roots of Morus nigra. It is used for studies on tyrosinase inhibition and natural flavanone glycosides.
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Tec-IN-6
0 ImagesCat. No.: HY-123541CAS No.: 923762-87-2
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Tyrosinase-IN-28
0 ImagesCat. No.: HY-162524Tyrosinase-IN-28 (Compound 4l) is an inhibitor for tyrosinase with IC50 of 72.55 μM, by affecting both substrate binding and enzyme catalysis.
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Benzylideneacetone (Standard)
0 ImagesSynonyms: Benzalacetone (Standard)Benzylideneacetone (Standard) is the analytical standard of Benzylideneacetone. This product is intended for research and analytical applications. Benzylideneacetone (Benzalacetone) is an orally active antibiotic, tyrosinase inhibitor, phospholipase A2 inhibitor, and immunosuppressant. Benzylideneacetone has antibacterial activity against some gram-negative plant-pathogenic bacteria. Benzylideneacetone can also be used in the synthesis of chemicals and drugs, and as a flavoring additive for some foods.
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Tyrosinase-IN-26
0 ImagesCat. No.: HY-158021Tyrosinase-IN-26 (compound 13) is a uncompetitive tyrosinase inhibitor with the an IC50 value of 68.86 µM. Tyrosinase-IN-26 can suppresses melanogenesis.
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Tyrosinase-IN-15
0 ImagesCat. No.: HY-156370Tyrosinase-IN-15 (Compound 39) is a tyrosinase inhibitor (IC50: 7.12 μM, Ki: 11.8 μM).
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MB-m-borate
0 ImagesCat. No.: HY-D3140MB-m-borate is a double-locked near-infrared fluorescence-activated probe (Ex/Em ≈ 647 nm/684 nm). MB-m-borate undergoes cascade activation by hydrogen peroxide and tyrosinase to release the fluorophore methylene blue, thereby generating a fluorescence activation response. MB-m-borate enables precise detection of melanoma in melanoma cells and mouse models. MB-m-borate can be used for melanoma research.
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Pseudostellarin G
0 ImagesCat. No.: HY-P6294CAS No.: 156525-71-2Pseudostellarin G is a natural cyclic octapeptide. Pseudostellarin G has the activity of inhibiting tyrosinase. Pseudostellarin G can inhibit the production of melanin.
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Tyrosinase-IN-7
0 ImagesTyrosinase-IN-7 is a potent tyrosinase inhibitor with an IC50 value of 1.57 µM. Tyrosinase-IN-7 inhibits cell growth with low cytotoxicity.
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Tyrosinase-IN-36
0 ImagesCat. No.: HY-162889Tyrosinase-IN-36 is a moderate Tyrosinase inhibitor, with an inhibition percentage of 42.75% at 100 μM compared to kojic acid, and it exhibits antioxidant activity.
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3-O-Ethyl-L-ascorbic acid (Standard)
0 Images3-O-Ethyl-L-ascorbic acid (Standard) is the analytical reference standard for 3-O-Ethyl-L-ascorbic acid. 3-O-Ethyl-L-ascorbic acid is a stable derivative of vitamin C and a cosmetic tyrosinase inhibitor. 3-O-Ethyl-L-ascorbic acid has antioxidant, anti-aging, and skin-whitening activities. 3-O-Ethyl-L-ascorbic acid is often used in the study of cosmetic.
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Tyrosinase-IN-46
0 ImagesCat. No.: HY-179619Tyrosinase-IN-46 (Compound III19) is a tyrosinase inhibitor. Its IC50 values for L-dopa and L-tyrosine are 3.24 and 2.79 nM respectively. Tyrosinase-IN-46 inhibits melanin synthesis and shows a significant anti-pigmentation effect. Tyrosinase-IN-46 can be used for the study of pigmentation disorders.
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MtTMPK-IN-4
0 ImagesCat. No.: HY-143452CAS No.: 2225889-49-4MtTMPK-IN-4 (compound 2), a para-piperidine, is a potent mycobacterium tuberculosis thymidylate kinase (MtTMPK) inhibitor with an IC50 of 6.1 μM. MtTMPK-IN-4 is a potent tyrosinase inhibitor. MtTMPK-IN-4 is a potent antibacterial agent.
