2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Apical Sodium-Dependent Bile Acid Transporter
  5. Apical Sodium-Dependent Bile Acid Transporter Activator

Apical Sodium-Dependent Bile Acid Transporter Activator

Apical Sodium-Dependent Bile Acid Transporter Activator (1):

Cat. No. Product Name Effect Purity
  • HY-104081
    Cholestyramine
    		Activator
    Cholestyramine (Cholestyramine resin) is an orally active bile acid sequestrant. Cholestyramine upregulates the expression of intestinal Apical sodium-dependent bile acid transporter and hepatic Cholesterol 7α-hydroxylase. Cholestyramine induces the expression of intestinal and hepatic cholesterol synthesis genes as well as hepatic lipogenesis genes, and promotes bile acid- and neutral sterol-mediated reverse cholesterol transport. Cholestyramine reduces intestinal cholesterol absorption and induces cholesterol efflux. Cholestyramine is applicable to research related to coronary artery disease, atherosclerotic cardiovascular disease and atherosclerosis.