2. Signaling Pathways
  3. Immunology/Inflammation
  4. CTLA-4
  5. CTLA-4 Degrader

CTLA-4 Degrader

CTLA-4 Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-179228
    AN02
    		Degrader
    AN02 is a derivative of Curcumin (HY-N0005). AN02 inhibits the proliferation and clonogenicity, migration and invasion of ovarian cancer cells. AN02 dose-dependently upregulates the expression of APC and mediates the degradation of CTLA-4 through SMAD4. In the small xenograft model, AN02 significantly inhibits tumor growth and reverses the tumor immune-suppressive microenvironment. AN02, when combined with Ipilimumab (HY-P9901), can enhance efficacy and inhibit epithelial-mesenchymal transition. AN02 can be used for the study of ovarian cancer.