Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Related Products (4032)
Related Products (4032)
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N,N-Diethyl hexylone hydrochloride
0 ImagesCat. No.: HY-168835CAS No.: 17763-17-6N,N-Diethyl hexylone hydrochloride is a drug derivative.
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Hispidone
0 ImagesCat. No.: HY-N4041CAS No.: 73891-72-2Hispidone is a natural triterpene.
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α-Obscurine derivative-1
0 ImagesCat. No.: HY-177955CAS No.: 3093625-46-5α-Obscurine derivative-1 (Compound 7) is a α-Obscurine (HY-134036) derivative. α-Obscurine derivative-1 inhibits CaV3.1 ion channel current with an IC50 of 0.19 μM. α-Obscurine derivative-1 can be used in the research of neurological disorders.
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Antibacterial agent 374
0 ImagesCat. No.: HY-189254CAS No.: 3134063-12-7Antibacterial agent 374 is a heterocycle-substituted α-methylene-γ-butyrolactone derivative with anti-phytopathogenic bacteria activity. Antibacterial agent 374 exhibits activity against Pseudomonas syringae pv. actinidiae, with EC50 = 12.07 mg/L. Antibacterial agent 374 shows protective activity against kiwifruit bacterial canker in a kiwifruit cane in vivo model. Antibacterial agent 374 can be used for research related to bacterial infections.
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16-Oxodiepiserratenediol
0 ImagesCat. No.: HY-N1761CAS No.: 24513-51-7Synonyms: 3alpha,21beta-Dihydroxyserrat-14-en-16-one16-Oxodiepiserratenediol (3alpha,21beta-Dihydroxyserrat-14-en-16-one) is a natural triterpene.
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Zataroside B
0 ImagesCat. No.: HY-N16809CAS No.: 95645-52-6Zataroside B is a natural terpenoid.
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Hazelnutin F
0 ImagesCat. No.: HY-N18281CAS No.: 2765860-33-9Hazelnutin F is an indoleacetic acid glycoside found in the kernels of Corylus avellana L.. Hazelnutin F lacks significant antioxidant activity against ABTS and DPPH radicals.
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8-Methyldisporopsin 4'-methyl ether
0 ImagesCat. No.: HY-N17130CAS No.: 1589545-88-98-Methyldisporopsin 4'-methyl ether is a natural flavonoid.
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(2E,4Z,8E)-Dehydropipernonaline
0 ImagesCat. No.: HY-N12122ACAS No.: 922143-65-5(2E,4Z,8E)-Dehydropipernonaline is a natural product that can be found in Biba.
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WEB2347
0 ImagesCat. No.: HY-118708CAS No.: 114800-19-0WEB2347 is an active compound.
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2′,3′-cGMP triethylamine
0 ImagesCat. No.: HY-138079CAS No.: 73647-09-3Synonyms: Guanosine 2',3'-cyclic phosphate triethylamine2′,3′-cGMP triethylamine (Guanosine 2',3'-cyclic phosphate triethylamine) is an active compound. 2′,3′-cGMP triethylamine can be used for various studies.
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SC-60
0 ImagesCat. No.: HY-W717425CAS No.: 1421677-31-7SC-60 is a derivative of Sorafenib (HY-10201). SC-60 exerts its anti-tumor effect by activating the phosphatase activity of SHP-1, thereby inhibiting the STAT3 signaling pathway. SC-60 exhibits strong proliferation inhibitory activity in various hepatocellular carcinoma (HCC) cell lines. SC-60 downregulates the expression of downstream anti-apoptotic proteins (such as Bcl-2, Cyclin D1, Survivin), ultimately inducing caspase-dependent apoptosis. SC-60 significantly inhibits tumor growth in xenograft tumor models. SC-60 can be used for the study of HCC.
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Tenuifoliose Q
0 ImagesCat. No.: HY-N18287CAS No.: 662166-93-0Tenuifoliose Q is an oligosaccharide ester esterified with acetic acid, benzoic acid and p-hydroxycinnamic acid, which can be isolated from the root bark of Polygala tenuifolia Willd.
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Ophiopogonanone H
0 ImagesCat. No.: HY-N7936CAS No.: 1427086-65-4Ophiopogonanone H is a natural product that can be found in Ophiopogon japonicus?(L. f.) Ker Gawl..
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Ageratochromene dimer
0 ImagesCat. No.: HY-N9054CAS No.: 17678-76-1Synonyms: Precocene II dimerAgeratochromene dimer (Precocene II dimer) is a natural phenolic compound.
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CGP 29030A
0 ImagesCat. No.: HY-106935ACAS No.: 113240-27-0CGP 29030A is an orally effective and specific analgesic agent. CGP 29030A inhibits nociceptive spinal cord neurons without affecting normal sensory functions. CGP 29030A also inhibits gamma motor neurons, which may be beneficial for studying pain disorders that occur concurrently due to increased motor activity (such as cramp, spasm).
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Sp-GTPαS
0 ImagesCat. No.: HY-137614CAS No.: 81570-51-6Sp-GTPαS is a phosphonothioate analog of GTP (HY-113225). Sp-GTPαS is more metabolically stable than GTP.
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LY307452
0 ImagesCat. No.: HY-120077CAS No.: 174393-13-6LY307452 is an active compound.
