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Cat. No.: HY-189254

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Antibacterial agent 374

Antibacterial agent 374 is a heterocycle-substituted α-methylene-γ-butyrolactone derivative with anti-phytopathogenic bacteria activity. Antibacterial agent 374 exhibits activity against Pseudomonas syringae pv. actinidiae, with EC₅₀ = 12.07 mg/L. Antibacterial agent 374 shows protective activity against kiwifruit bacterial canker in a kiwifruit cane in vivo model. Antibacterial agent 374 can be used for research related to bacterial infections.

For research use only. We do not sell to patients.

CAS No.: 3134063-12-7
Formula: C₂₀H₁₅F₃O₄
Molecular Weight:376.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antibacterial agent 374 Chemical Structure

CAS No.: 3134063-12-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

Antibacterial agent 374 (compound B12) (50 mg/L; 24-48 h) exhibits potent in vitro antibacterial activity against Pseudomonas syringae pv actinidiae, with an EC₅₀ of 12.07 mg/L^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Antibacterial agent 374 (compound B12) (100-200 mg/L) provides 52.2% protection against kiwifruit bacterial canker caused by Psa at a concentration of 100 mg/L, and 72.3% protection at a concentration of 200 mg/L^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3134063-12-7
Molecular Weight 376.33
Formula C₂₀H₁₅F₃O₄
SMILES

C=C1C(OC(C2=CC=C(C(F)(F)F)C=C2)C1C3=CC4=C(C=C3)OCCO4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yang D, et al. Heterocycle-Substituted α-Methylene-γ-Butyrolactone Derivatives: Design, Synthesis, and Bioactivity against Phytopathogenic Fungi and Bacteria. Journal of agricultural and food chemistry. 2026 Aug 19;74(32):25003-25017.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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