Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Related Products (4032)
Related Products (4032)
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Olanzapine-lactam
0 ImagesSynonyms: LY301664Olanzapine-lactam (LY301664) is a specific impurity of Olanzapine (HY-14541) as well as its potential metabolite.
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trans-4-Hydroxyprolinol-C10-tri-GalNAc
0 ImagesCat. No.: HY-171987CAS No.: 1469730-77-5trans-4-Hydroxyprolinol-C10-tri-GalNAc (Formula XXIV) is a Tri-GaINAc derivative that can be used for nucleic acid drug coupling.
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Petalostemumol G
0 ImagesCat. No.: HY-N13858CAS No.: 152253-69-5Petalostemumol G is a flavonol derivative present in Petalostemum purpureum. Petalostemum G has no antibacterial activity. Petalostemumol G is formed by air oxidation of petalostemumol.
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WAY-606376
0 ImagesWAY-606376 is an active molecule.
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(R)-(+)-Docosahexaenyl-1'-hydroxy-2'-propylamide
0 ImagesCat. No.: HY-W742938CAS No.: 1282618-08-9(R)-(+)-Docosahexaenyl-1'-hydroxy-2'-propylamide is a polyunsaturated fatty acid amide with anti-proliferative properties.
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D-Biotinol (Standard)
0 ImagesCat. No.: HY-W096159RCAS No.: 53906-36-8D-Biotinol (Standard) is the analytical standard of D-Biotinol (HY-W096159). This product is intended for research and analytical applications. D-Biotinol is an orally effective alcohol analogue of D-Biotin (HY-B0511). D-Biotinol can replace D-biotin to restore the biotin deficiency induced by egg whites in rats. D-Biotinol can be used for the study of biotin deficiency disorders.
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Phosmidosine C
0 ImagesCat. No.: HY-N15111CAS No.: 146425-26-5Phosmidosine C is a phosmidosine derivative.
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Bromoriluzole
0 ImagesCat. No.: HY-W166106CAS No.: 144631-82-3Bromoriluzole is a derivative of Riluzole (HY-B0211). Bromoriluzole inhibits Ca2+ -dependent Calmodulin-SK4 channel interaction. Bromoriluzole is used for the research of neurodegenerative diseases.
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Pseudovardenafil
0 ImagesCat. No.: HY-W588234CAS No.: 224788-34-5Synonyms: PiperidenafilPseudovardenafil is a new Vardenafil (HY-B0442) analog illegally added to dietary supplements.
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TCEP hydrobromide (Standard)
0 ImagesCat. No.: HY-W011500RCAS No.: 51805-45-9Synonyms: Tris(2-carboxyethyl)phosphine hydrochloride (Standard)TCEP hydrochloride (Standard) is the analytical standard of TCEP hydrochloride (HY-W011500). This product is intended for research and analytical applications. TCEP hydrochloride (Tris(2-carboxyethyl)phosphine hydrochloride) is a non-thiol reducing agent that is more stable and produces a faster S-S reductive reaction than other chemical reductants. TCEP hydrochloride is a trialkylphosphine, selectively reduces protein disuldes without altering the properties or interacting with thiol-directed agents in the reaction mixture. TCEP hydrochloride is also a commonly used reducing agent in the DNA/AuNP chemistry.
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Antiparasitic agent-39
0 ImagesCat. No.: HY-180943CAS No.: 2568585-37-3Antiparasitic agent-39 (Compound 14) is a selective antiparasitic agent and Deferasirox (HY-17359) derivative. Antiparasitic agent-39 reduces the mitochondrial membrane potential. Antiparasitic agent-39 shows antiparasitic activity against T. brucei, T. gambiense, L. Mexicana, T. gondii, B. divergens, P. falciparum with EC50s of 4.2 nM, 10.4 nM, 52.0 nM, 17.0 nM, 41.2 nM, 54.8 nM, respectively.
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Mipragoside
0 ImagesCat. No.: HY-105210CAS No.: 131129-98-1Mipragoside is a ganglioside derivative. Mipragoside can be studied in research on ocular inflammatory diseases such as keratoconjunctivitis.
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Ethonam
0 ImagesCat. No.: HY-184509CAS No.: 15037-44-2Ethonam is the non-salt form of Ethonam nitrat. Ethonam nitrat exhibits antifungal activity against Microsporum canis, Trichophyton mentagrophytes and Trichophyton rubrum. Ethonam can be used in research related to fungal infections.
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Sitosteryl maltoside
0 ImagesCat. No.: HY-185004CAS No.: 40653-10-9Sitosteryl maltoside is a steryl glucoside. Sitosteryl maltoside can be used in studies on the growth of Avena coleoptile segments.
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2-Ethyl-5-methylphenol
0 Images2-Ethyl-5-methylphenol is an aromatic compound that can be detected in breakfast cereals, cereals and grain products.
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C12 NBD phytoceramide (t18:0/12:0)
0 ImagesCat. No.: HY-175055Synonyms: C12 NBD phytosphingosine (t18:0/12:0); NBD cer (t18:0/12:0); NBD ceramide (t18:0/12:0)C12 NBD Phytoceramide (t18:0/12:0) is a ceramide analogue composed of a phytoceramide and green fluorescent C12 NBD. C12 NBD Phytoceramide (t18:0/12:0) is a fluorescent substrate (Ex=485 nM, Em=525 nM) and can be used to detect ceramidase (such as diacylglycerol acyltransfereases Lro1p) activity.
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H-D-Tpi-OH
0 ImagesCat. No.: HY-W269285CAS No.: 72002-54-1Synonyms: D-1,2,3,4-Tetrahydronorharman-3-carboxylic acidH-D-Tpi-OH (D-1,2,3,4-Tetrahydronorharman-3-carboxylic acid) is a tetrahydro-β-carboline derivative. H-D-Tpi-OH only slightly upregulates QR1, mildly inhibits the aromatase and NO synthesis pathways, and shows no significant in vitro anti-breast tumor proliferation activity. H-D-Tpi-OH can be used in cancer-related research.
