Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Related Products (4062)
Related Products (4062)
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Dihydrojasmonic acid (Standard)
0 ImagesCat. No.: HY-131116RCAS No.: 3572-64-3Dihydrojasmonic acid (Standard) is the analytical standard of Dihydrojasmonic acid (HY-131116). This product is intended for research and analytical applications. Dihydrojasmonic acid is a pentacyclic oxygen-containing lipid plant growth regulator related to Jasmonic acid (HY-122464), with activities including growth inhibition, promotion of leaf senescence, and induction of the accumulation of some plant secondary metabolites. Dihydrojasmonic acid serves as a substrate for metabolic modification and undergoes biotransformation via side-chain hydroxylation, glycosylation, and amino acid conjugation in the aerial parts and seedlings of barley (Hordeum vulgare). Dihydrojasmonic acid inhibits the growth of dwarf rice seedlings and can induce the synthesis of secondary metabolites in some plant cell culture species, with its activity being species-dependent. Dihydrojasmonic acid is involved in studies related to the regulation of plant growth and development.
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N,N-Dimethyl-3,4-DMA hydrochloride
0 ImagesCat. No.: HY-170742CAS No.: 70932-19-3Synonyms: 3,4-Dimethoxydimethylamphetamine hydrochlorideN,N-Dimethyl-3,4-DMA (3,4-Dimethoxydimethylamphetamine) hydrochloride is an amphetamine.
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PBITC
0 ImagesCat. No.: HY-W679796CAS No.: 61499-10-3Synonyms: 4-Phenylbutyl isothiocyanate
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3-Chloropropane-1,2-diol dipalmitate (Standard)
0 ImagesCat. No.: HY-W585819RCAS No.: 51930-97-3Synonyms: 3-MPCD dipalmitate (Standard); 3-CPD dipalmitate (Standard)3-Chloropropane-1,2-diol dipalmitate (3-MPCD dipalmitate) Standard is the analytical standard of 3-Chloropropane-1,2-diol dipalmitate (HY-W585819). This product is intended for research and analytical applications. 3-Chloropropane-1,2-diol dipalmitate (3-MPCD dipalmitate) is a fatty acid ester of 3-monochloropropane-1,2-diol (3-MCPD) and a foodborne contaminant.
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2-(3-Chloropropyl)isoindoline-1,3-dione
0 ImagesCat. No.: HY-W103365CAS No.: 42251-84-32-(3-Chloropropyl)-1H-isoindole-1,3(2H)-dione is a tranquilizing agent that belongs to the class of indazoles.
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β-Ionone acid
0 Imagesβ-Ionone acid, an analog of β-Ionone, is a promising anticancer agent.
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3-Methylbuphedrone hydrochloride
0 ImagesCat. No.: HY-W704916CAS No.: 1797911-07-93-Methylbuphedrone hydrochloride is a methylated analog of Buphedrone.
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1-Dehydrocorticosterone 21-acetate
0 ImagesCat. No.: HY-W744098CAS No.: 58652-04-3Synonyms: 1-DHC 21-acetate1-Dehydrocorticosterone 21-acetate is an acetylated derivative of corticosterone (HY-B1618) that is dehydrogenated at the one position. It has been used as a precursor in the synthesis of 21-hydroxypregna-1,4-diene-3,11,20-trione, which is a metabolite of 1α-hydroxycorticosterone in the skate.
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Photoclick palmitic acid
0 ImagesCat. No.: HY-179548CAS No.: 2988174-40-7Photoclick palmitic acid is a derivative of the long-chain saturated fatty acid palmitic acid (HY-N0830). The photoclick-type long-chain saturated fatty acid has been used as a probe for studying protein lipidation.
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α-Thujenal
0 ImagesCat. No.: HY-N19843CAS No.: 57129-54-1α-Thujenal is a derivative of Thujene that can be isolated from the leaves of Laurus nobilis L..
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Guanosine 5'-diphosphate-7'N-Me-Imidazole disodium
0 ImagesCat. No.: HY-174295Guanine nucleotide imidazolide intermediate (Compound 19e) disodium is a guanine nucleotide derivative that can be used to synthesize modified RNA.
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2-Hydroxy-atrazine
0 ImagesCat. No.: HY-W704138CAS No.: 2163-68-02-Hydroxy-atrazine is a non-herbicidal primary photoproduct that results from the hydrolytic dechlorination of atrazine.
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Benzyl salicylate (Standard)
0 ImagesBenzyl salicylate (Standard) (NSC 6647 (Standard)) is the analytical standard of Benzyl salicylate (HY-B1556). This product is intended for research and analytical applications. Benzyl salicylate (NSC 6647)?is a salicylic acid benzyl ester. It can be used as a fragrance additive or UV light absorber.
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3-MAPB hydrochloride
0 ImagesCat. No.: HY-W711329CAS No.: 2748304-55-23-MAPB hydrochloride is a benzofuran compound.
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Glycodeoxycholic acid-3-O-b-glucuronide disodium
0 ImagesCat. No.: HY-W587912CAS No.: 75672-36-5Glycodeoxycholic acid-3-O-b-glucuronide disodium is a β-D-glucopyranosiduronic acid derivative.
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2-(Cyclohexylmethyl)-plumbagin
0 ImagesCat. No.: HY-169830CAS No.: 3033734-59-42-(Cyclohexylmethyl)-plumbagin is a derivative of the naphthoquinone compound Plumbagin (HY-N1497). Under nutrient-deprived conditions, 2-(Cyclohexylmethyl)-plumbagin selectively exhibits cytotoxicity against PANC-1 human pancreatic cancer cells (PC50 = 0.11 µM) and reduces the phosphorylation of Akt and mTOR in PANC-1 cells. 2-(Cyclohexylmethyl)-plumbagin also induces apoptosis (Apoptosis) in PANC-1 cells at a concentration of 1 µM. Additionally, 2-(Cyclohexylmethyl)-plumbagin reduces tumor volume and weight in a xenograft MiaPaCa-2 pancreatic cancer mouse model.
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JAX-44
0 ImagesCat. No.: HY-178358CAS No.: 2352652-76-5JAX-44 is a potent root architecture modulator. JAX-44 maintains primary root length while substantially increasing lateral root numbers, thereby optimizing the plant’s overall root system. JAX-44 is the metabolic precursor of JAX-77 (HY-178359) and can be converted to Indole-3-butyric acid (IBA) (HY-N0186). JAX-44 can be used for auxin biology and root development research.
