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2-(Cyclohexylmethyl)-plumbagin

2-(Cyclohexylmethyl)-plumbagin is a derivative of the naphthoquinone compound Plumbagin (HY-N1497). Under nutrient-deprived conditions, 2-(Cyclohexylmethyl)-plumbagin selectively exhibits cytotoxicity against PANC-1 human pancreatic cancer cells (PC50 = 0.11 µM) and reduces the phosphorylation of Akt and mTOR in PANC-1 cells. 2-(Cyclohexylmethyl)-plumbagin also induces apoptosis (Apoptosis) in PANC-1 cells at a concentration of 1 µM. Additionally, 2-(Cyclohexylmethyl)-plumbagin reduces tumor volume and weight in a xenograft MiaPaCa-2 pancreatic cancer mouse model.

For research use only. We do not sell to patients.

  • CAS No.: 3033734-59-4
  • Formula: C17H18O3
  • Molecular Weight:270.32
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • 2-(Cyclohexylmethyl)-plumbagin Chemical Structure
    2-(Cyclohexylmethyl)-plumbagin Chemical Structure
CAS No.: 3033734-59-4
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    2-(Cyclohexylmethyl)-plumbagin Chemical Structure
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  • 2-(Cyclohexylmethyl)-plumbagin