3033734-59-4

2-(Cyclohexylmethyl)-plumbagin Chemical Structure
3033734-59-4

Chemical Structure

2-(Cyclohexylmethyl)-plumbagin

  • CAS No.: 3033734-59-4
  • Formula:C17H18O3
  • Molecular Weight:270.32

InChIKey: RVEVRWXGYBTXKU-UHFFFAOYSA-N

SMILES: O=C1C=C(CC2CCCCC2)C(C3=C1C(O)=CC=C3)=O

Biological Activity: 2-(Cyclohexylmethyl)-plumbagin is a derivative of the naphthoquinone compound Plumbagin (HY-N1497). Under nutrient-deprived conditions, 2-(Cyclohexylmethyl)-plumbagin selectively exhibits cytotoxicity against PANC-1 human pancreatic cancer cells (PC50 = 0.11 µM) and reduces the phosphorylation of Akt and mTOR in PANC-1 cells. 2-(Cyclohexylmethyl)-plumbagin also induces apoptosis (Apoptosis) in PANC-1 cells at a concentration of 1 µM. Additionally, 2-(Cyclohexylmethyl)-plumbagin reduces tumor volume and weight in a xenograft MiaPaCa-2 pancreatic cancer mouse model[1].

Cat. No. Product Name Purity Description Pricing
HY-169830 		2-(Cyclohexylmethyl)-plumbagin 2-(Cyclohexylmethyl)-plumbagin is a derivative of the naphthoquinone compound Plumbagin (HY-N1497). Under nutrient-deprived conditions, 2-(Cyclohexylmethyl)-plumbagin selectively exhibits cytotoxicity against PANC-1 human pancreatic cancer cells (PC50 = 0.11 µM) and reduces the phosphorylation of Akt and mTOR in PANC-1 cells. 2-(Cyclohexylmethyl)-plumbagin also induces apoptosis (Apoptosis) in PANC-1 cells at a concentration of 1 µM. Additionally, 2-(Cyclohexylmethyl)-plumbagin reduces tumor volume and weight in a xenograft MiaPaCa-2 pancreatic cancer mouse model.
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