Cat. No.: HY-B1556

Benzyl salicylate

(Synonyms: NSC 6647)

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Based on 1 Customer Validation

Benzyl salicylate (NSC 6647)?is a salicylic acid benzyl ester. It can be used as a fragrance additive or UV light absorber.

For research use only. We do not sell to patients.

Purity: 99.78%
CAS No.: 118-58-1
Formula: C₁₄H₁₂O₃
Molecular Weight:228.25

Storage:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Benzyl salicylate Chemical Structure

CAS No.: 118-58-1

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Benzyl salicylate (NSC 6647)?is a salicylic acid benzyl ester. It can be used as a fragrance additive or UV light absorber^[1].

All p38 MAPK Isoforms :

All JNK Isoforms :

All ERK Isoforms :

In Vitro

Benzyl salicylate (10-100 μM, 24 h) inhibits Cisplatin (HY-17394)-induced apoptosis and ROS generation, attenuates Cisplatin (HY-17394)-induced nephrotoxicity through inhibition of JNK/ERK/p38 signaling pathway^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[2]

Cell Line:

LLC-PK1
Concentration:

10-100 μM
Incubation Time:

24 h
Result:

Inhibited Cisplatin-induced apoptosis.

Western Blot Analysis^[2]

Cell Line:

LLC-PK1
Concentration:

10-100 μM
Incubation Time:

24 h
Result:

Increased the level of Bcl-2, reduced the level of Bax and cleaved caspase-3/9.

In Vivo

Benzyl salicylate (30-300 mg/kg, po, once daily for 40-46 days) causes embryonic resorption, offspring mortality, neural tube defects (300 mg/kg), exhibits teratogenicity in rats models^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley rats models^[3]
Dosage:

30-300 mg/kg
Administration:

po, once daily for 40-46 days
Result:

Reduced the organ weights of rats. Prolonged the gestation period and decreased the number of live offspring.

Chemical Information

CAS No. 118-58-1
Appearance Liquid (Density: 1.1751 g/cm³)
Molecular Weight 228.25
Formula C₁₄H₁₂O₃
Color Colorless to light yellow
SMILES

O=C(OCC1=CC=CC=C1)C2=CC=CC=C2O
Synonyms

NSC 6647
Structure Classification
- Phenols
- Monophenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (438.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.3812 mL

21.9058 mL

43.8116 mL

5 mM

0.8762 mL

4.3812 mL

8.7623 mL

10 mM

0.4381 mL

2.1906 mL

4.3812 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (10.95 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (10.95 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (10.95 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. María A Pastor-Nieto, et al. Sensitization to benzyl salicylate and other allergens in patients with frontal fibrosing alopecia. Contact Dermatitis. 2021 Jun;84(6):423-430. [Content Brief]

[2]. Lee D, et al., Benzyl salicylate from the stems and stem barks of Cornus walteri as a nephroprotective agent against cisplatin-induced apoptotic cell death in LLC-PK1 cells. RSC Adv. 2020 Feb 5;10(10):5777-5784. [Content Brief]

[3]. Igarashi T, et al., Initial hazard assessment of benzyl salicylate: In vitro genotoxicity test and combined repeated-dose and reproductive/developmental toxicity screening test in rats. Regul Toxicol Pharmacol. 2018 Dec;100:105-117. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.3812 mL	21.9058 mL	43.8116 mL	109.5290 mL
	5 mM	0.8762 mL	4.3812 mL	8.7623 mL	21.9058 mL
	10 mM	0.4381 mL	2.1906 mL	4.3812 mL	10.9529 mL
	15 mM	0.2921 mL	1.4604 mL	2.9208 mL	7.3019 mL
	20 mM	0.2191 mL	1.0953 mL	2.1906 mL	5.4765 mL
	25 mM	0.1752 mL	0.8762 mL	1.7525 mL	4.3812 mL
	30 mM	0.1460 mL	0.7302 mL	1.4604 mL	3.6510 mL
	40 mM	0.1095 mL	0.5476 mL	1.0953 mL	2.7382 mL
	50 mM	0.0876 mL	0.4381 mL	0.8762 mL	2.1906 mL
	60 mM	0.0730 mL	0.3651 mL	0.7302 mL	1.8255 mL
	80 mM	0.0548 mL	0.2738 mL	0.5476 mL	1.3691 mL
	100 mM	0.0438 mL	0.2191 mL	0.4381 mL	1.0953 mL

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Benzyl salicylate

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All p38 MAPK Isoforms

All JNK Isoforms

All ERK Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Benzyl salicylate Related Classifications

HY-B1556 Related Classifications