Bromoriluzole
Bromoriluzole is a derivative of Riluzole (HY-B0211). Bromoriluzole inhibits Ca2+ -dependent Calmodulin-SK4 channel interaction. Bromoriluzole is used for the research of neurodegenerative diseases.
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- CAS. Nr.: 144631-82-3
- Formel: C8H4BrF3N2OS
- Molecular Weight:313.09
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Bromoriluzole (Compound 1) (100 μM) inhibits Ca2+-dependent interactions between calmodulin and the SK4 channel S4S5 linker (measured via FRET biosensor) with a total amplitude inhibition of 24.1% and Phase II amplitude inhibition of 31.2% at 100 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 144631-82-3
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Appearance solid
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Molecular Weight 313.09
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Formel C8H4BrF3N2OS
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SMILES
FC(F)(F)OC=1C=C(Br)C=2N=C(SC2C1)N
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
Verweise
[1]. Baltasar-Marchueta M, et al. Identification of Riluzole derivatives as novel calmodulin inhibitors with neuroprotective activity by a joint synthesis, biosensor, and computational guided strategy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 May;174:116602. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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