2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. HMG Family
  5. HMG Family Modulator

HMG Family Modulator

HMG Family Modulator (1):

Cat. No. Product Name Effect Purity
  • HY-181546
    Ibt-DOX
    		Modulator
    Ibt-DOX is a BTK inhibitor with an IC50 of 2.89 nM. Ibt-DOX is also a targeted covalent activated chemotherapeutic agent composed of the targeting ligand Ibrutinib (HY-10997), Doxorubicin (DOX) (HY-15142A), α-MAA (HY-W017180), and a linker (HY-Y0892). Ibt-DOX specifically binds to BTK and releases DOX, synergistically achieving BTK inhibition and chemotherapeutic killing, significantly enhancing toxicity against B-cell lymphoma cells and greatly reducing the toxic side effects of DOX on BTK-negative cells. Ibt-DOX can be used in lymphoma-related research.