HPPD Inhibitor

Isoxaflutole (Standard) is the analytical standard of Isoxaflutole. This product is intended for research and analytical applications. Isoxaflutole (Merlin) is the inhibitor for HPPD that blocks benzoquinone biosynthesis, and results in the bleaching of weeds.

AtHPPD-IN-1 (Compound III-15) is an HPPD inhibitor and herbicide with high safety for peanuts. AtHPPD-IN-1 has IC₅₀ of 12 nM for Arabidopsis thaliana HPPD.

Biscarfentrazone is a HPPD-inhibiting herbicide for wheat fields, which can effectively control ALS-resistant broadleaf weeds and is safe to wheat.

Tembotrione (Standard) is the analytical standard of Tembotrione. This product is intended for research and analytical applications. Tembotrione is a drug that may reduce the productivity of carrots. Tembotrione has the activity of reducing carrot stem mass. Tembotrione can be used to study the total productivity of carrot . Tembotrione is a herbicide belonging to the HPPD (dioxygenase) inhibitor class with crop selectivity. Tembotrione effectively controls a variety of weeds including broadleaf and gramineous species by disrupting carotenoid synthesis, which leads to chlorophyll degradation and leaf whitening. Mixing Tembotrione with isoxaflutole or adding surfactants optimizes its efficacy and reduces phytotoxicity, with no residual impact on subsequent cruciferous crops, thus helping to increase maize grain yield. The activity of Tembotrione decreases under drought conditions, and under specific conditions (such as double-dose treatment), it may cause reversible yellowing and even yield reduction in crops such as poppy.

HPPD-IN-11 is an inhibitor of Arabidopsis thaliana 4-hydroxyphenylpyruvate dioxygenase (AtHPPD), with a K_i value of 0.016 μM, and exhibits herbicidal activity. HPPD-IN-11 enhances π-π interactions with Phe360 and Phe403 in the active site of AtHPPD, thereby strengthening its enzyme-binding ability. HPPD-IN-11 can be used in studies related to weed damage.

HPPD-IN-12 is an inhibitor of Arabidopsis thaliana 4-hydroxyphenylpyruvate dioxygenase (AtHPPD), with an IC₅₀ of 27.8 μM and a K_d of 1.535 μM. HPPD-IN-12 binds to AtHPPD via Fe²⁺ coordination, π-π interactions and hydrogen bonds. HPPD-IN-12 can be used in herbicide-related research.

Fenpyrazone is a 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor as well as a post-emergence herbicide. By inhibiting the activity of HPPD, Fenpyrazone indirectly blocks carotenoid biosynthesis in plants, causing bleaching of new tissues in sensitive plants, followed by necrosis and eventual death. Fenpyrazone is used in studies on controlling annual monocotyledonous and dicotyledonous weeds in summer maize fields.

RPA 202248 is a p-hydroxy phenyl pyruvate dioxygenase (HPPD) inhibitor and degradation product of Isoxaflutole (HY-116139). RPA 202248 demonstrates environmental persistence and undergoes transport through soil matrix and macropores to subsurface drain flow in agricultural field settings.

HPPD-IN-9 is a 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor with an IC₅₀ of 0.21 μM against Arabidopsis thaliana. HPPD-IN-9 acts as a herbicide and exhibits activity against weed species. HPPD-IN-9 is applicable to herbicidal research.

Flusulfinam is a HPPD inhibitor and herbicide, with an IC₅₀ of 0.0181 μM against Arabidopsis thaliana HPPD. Flusulfinam inhibits the catalytic activity of recombinant Arabidopsis thaliana HPPD. Flusulfinam exhibits potent herbicidal activity against barnyard grass (Echinochloa crus-galli). Flusulfinam inhibits the growth of Digitaria sanguinalis.

Tolpyralate is a selective post-emergence herbicide and corn Herbicide. Tolpyralate inhibits 4-HPPD. Tolpyralate exhibits herbicidal activity against a variety of weeds, including the glyphosate-resistant weed Amaranthus tuberculatus.

HPPD-IN-5 (compound IV-45) is a 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor with an IC₅₀ of 0.21 μM. HPPD-IN-5 is used as a herbicide.

HPPD/PPO-IN-1 (Compound B14) is dual-functional inhibitor of HPPD and PPO with IC₅₀s of 0.12  μM and 0.51 μM for Arabidopsis thaliana HPPD and Nicotiana tabacum PPO, respectively. HPPD/PPO-IN-1 has broad-spectrum herbicidal activity against weeds with a crop safety to peanuts and cotton. HPPD/PPO-IN-1 can be used for the development of environmentally friendly herbicides.

HPPD-IN-4 is a Herbicide and HPPD inhibitor with an IC₅₀ of 0.19 μM against Arabidopsis thaliana HPPD. HPPD-IN-4 disrupts carotenoid biosynthesis and exhibits post-emergence herbicidal activity against Abutilon theophrasti and Chenopodium album.

Quinclorac (Standard) is the analytical standard of Quinclorac (HY-B0871). This product is intended for research and analytical applications. Quinclorac is a highly selective quinoline carboxylic acid synthetic auxin herbicide. Quinclorac weakly inhibits HPPD, accompanied by a transient decrease in carotenoids. Quinclorac upregulates ACC synthase (ACS), leading to the co-accumulation of ethylene and cyanide, while increasing the ABA/IAA ratio, which induces ROS burst, membrane lipid peroxidation (MDA) and lethal growth inhibition. Residual Quinclorac in soil can cause abnormal growth of subsequent tobacco crops. In calli of Phaseolus vulgaris, Quinclorac induces oxidative stress (increased MDA and decreased RGR), but cells after stepwise pressurized acclimation acquire a constitutive antioxidant state, which remains stable after de-acclimation and tolerates oxidative damage caused by Quinclorac. Quinclorac can be used in studies related to herbicide action mechanisms, bioremediation of soil residues, and adaptive responses of plant cells to oxidative stress.