Liposome

Liposomes (NPs typically 100–500 nm in diameter) are fabricated from the self-assembly of phospholipids, which consist of a polar phosphate head group and hydrophobic lipid tails. In aqueous environments, the hydrophobic tails self-orient, resulting in a spherical structure comprised of an aqueous core surrounded by a lipophilic bilayer membrane. Liposomes are both biocompatible and biodegradable (e.g., at certain pH and temperature), which can be controlled by modifying the lipid composition. Furthermore, liposomes are amenable to various modifications that improve their efficacy as drug delivery carriers.

References:

[1]. Almeida B, Nag OK, Rogers KE, Delehanty JB. Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery. Molecules. 2020;25(23):5672. Published 2020 Dec 1. [Content Brief]

Liposome Related Products (1006):

By Effects:	Inhibitors (2) Controls (2) Substrate (1) Modulator (1) Chemicals (8)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-159861

Ionizable Lipid 4
Ionizable Lipid 4 is an ionizable cationic lipid and a rearrangement product of the cationic lipid CA-lipid 5 induced by hydrogen peroxide.

HY-W441002R

DSPE-succinic acid (Standard)
Taurine (Standard) is the analytical standard of Taurine. This product is intended for research and analytical applications. Taurine, a sulphur-containing amino acid and an organic osmolyte involved in cell volume regulation, provides a substrate for the formation of bile salts, and plays a role in the modulation of intracellular free calcium concentration. Taurine has the ability to activate autophagy in adipocytes.

HY-150240A

18:1 Glutaryl PE monosodium
18:1 Glutaryl PE monosodium is a functionalized lipid.

HY-172495

DSPE-PEG3000-iRGD
DSPE-PEG3000-iRGD is a PEG compound which composed of DSPE and an αv-integrins targeting peptide (iRGD). iRGD peptide binds to αv-integrins, and then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties. DSPE-PEG3000-iRGD can be used for drug delivery.

HY-172479

DSPE-PEG2000-F3
DSPE-PEG2000-F3 is a PEG compound which composed of DSPE and a nucleolin targeting peptide (F3). F3 peptide can specifically bind to cell surface nucleolin and undergo an effective cell surface to nucleus transport. DSPE-PEG2000-F3 can be used for drug delivery.

HY-144012B

DPPE-PEG550
DPPE-PEG550 is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

HY-172470A

DSPE-PEG3400-GE11
DSPE-PEG3400-GE11 is a PEG compound which composed of DSPE and an EGFR targeting peptide (GE11). GE11 can be used for EGFR overexpressed cancer cells. DSPE-PEG3400-GE11 can be used for drug delivery.

HY-177205C

DSPE-PEG5000-CRPPR
DSPE-PEG5000-CRPPR is a PEG compound which composed of DSPE and a?Heart-homing peptide?(CRPPR) (HY-P10641). CRPPR is a linear peptide containing arginine that has the ability to specifically bind to the cardiac endothelium and uses cysteine-rich protein-2 (CRIP-2) as its receptor. DSPE-PEG5000-CGKRK can be used for drug delivery.

HY-W591449

DOPE-PEG2000-Azide
DOPE-PEG2000-Azide is a liposome to simulate biological phospholipid membrane. Liposomes are the main component of vesicles with concentric phospholipid bilayer membranes, which can be used to construct drug delivery systems for anti-cancer and anti-infection fields. Highly polar water-soluble payloads can be trapped in the internal aqueous space of liposomes, while lipophilic payloads can partition into and become part of the lipid bilayer. Especially for delivering antisense oligonucleotides, it can overcome problems such as inefficient cellular uptake and rapid loss in the body.

HY-142995

DODAP hydrochloride
DODAP (hydrochloride) is an ionizable lipid. DODAP (hydrochloride) has the potential for the research of gene delivery.

HY-172714A

DSPE-PEG3400-MPG
DSPE-PEG3400-MPG is a PEG compound which composed of DSPE and a peptide vector (MPG). MPG is derived from both the nuclear localisation sequence (NLS) of SV40 large T antigen and the fusion peptide domain of HIV-1 gp41. MPG could deliver short oligonucleotides into cells efficiently and independently of the endosomal pathway.

HY-172504

DSPE-PEG5000-Mal-Cys-KAAKNK
DSPE-PEG5000-KAA is a PEG compound which composed of DSPE and a CKAAKNK peptide (KAA). KAA specifically binds to tumor vessels in RIP-Tag2 transgenic mice. DSPE-PEG5000-KAA can be used for drug delivery.

HY-172479A

DSPE-PEG3400-F3
DSPE-PEG3400-F3 is a PEG compound which composed of DSPE and a nucleolin targeting peptide (F3). F3 peptide can specifically bind to cell surface nucleolin and undergo an effective cell surface to nucleus transport. DSPE-PEG3400-F3 can be used for drug delivery.

HY-172277B

DSPE-PEG5000-R9
DSPE-PEG5000-R9 is a PEG compound which composed of DSPE and a poly-arginine-9 peptide (R9). DSPE-PEG5000-R9 can be used for drug delivery.

HY-D2526

Cy3 IRGD-PEG-DSPE
Cy3 IRGD-PEG-DSPE is a PEG phospholipid with Cy3 (HY-D0822) dye used in protein/nucelic acid labeling and fluorescence microscopy. Cy3 IRGD-PEG-DSPE can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine.

HY-172489

DSPE-PEG5000-K237
DSPE-PEG5000-K237 is a PEG compound which composed of DSPE and a KDR targeting peptide (K237). K237 can functionally disrupt the interaction between VEGF and the KDR receptor and cause potent biological effects that include the inhibition of angiogenesis and tumor growth. DSPE-PEG5000-K237 can be used for drug delivery.

HY-171927

Lipid 12T-O14
Lipid 12T-O14 is a lipid nanoparticle. 12T-O14 facilitates local mRNA vaccine and systemic mRNA agent delivery.

HY-171905

N-Sterol
N-Sterol is a sterol lipid that has been used to generate lipid nanoparticles (LNPs) for delivery of mRNA in vitro and in vivo. N-Sterol LNPs are taken up in J774A.1 macrophages in a lipid composition-dependent manner via clathrin caveolae, caveolin-mediated endocytosis, micropinocytosis, or phagocytosis at different frequencies.

HY-W800777

6-(3-Hydroxypropylamino)hexyl 2-hexyldecanoate
6-(3-Hydroxypropylamino)hexyl 2-hexyldecanoate is an ionizable lipid which can be used to make ALC-0315. The lipid has an ester bond adjacent to C6 relative to the amine nitrogen. The introduction of ester linkages can improve the clearance of the lipid in the liver.

HY-172714

DSPE-PEG2000-MPG
DSPE-PEG2000-MPG is a PEG compound which composed of DSPE and a peptide vector (MPG). MPG is derived from both the nuclear localisation sequence (NLS) of SV40 large T antigen and the fusion peptide domain of HIV-1 gp41. MPG could deliver short oligonucleotides into cells efficiently and independently of the endosomal pathway.

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