2. Signaling Pathways
  3. GPCR/G Protein
  4. Mas-related G-protein-coupled Receptor (MRGPR)
  5. Mas-related G-protein-coupled Receptor (MRGPR) Inhibitor

Mas-related G-protein-coupled Receptor (MRGPR) Inhibitor

Mas-related G-protein-coupled Receptor (MRGPR) Inhibitors (2):

Cat. No. 상품명 효과 Purity
  • HY-172458
    Z-3578
    		Inhibitor 98.72%
    Z-3578 is an orally active small-molecule antagonist of MrgX2 with potent antipseudoallergic activity, exhibiting a KD value of 729 nM. Z-3578 effectively inhibits mast cell degranulation induced by substance P (SP) and C48/80, suppresses the release of β-hexosaminidase, significantly reduces the release of histamine and TNF-α, and decreases intracellular calcium flux. In a mouse pseudoallergy model, Z-3578 significantly alleviates paw swelling and dye extravasation, and reduces serum histamine levels. Z-3578 can be used for the study of pseudoallergic reactions.
  • HY-P11478
    Catestatin (mouse)
    		Inhibitor
    Catestatin (mouse) is an antimicrobial peptide. Catestatin (mouse) robustly activates Mrgprb2 with an EC50 of 59.73 μM. Catestatin (mouse) is effective in promoting MRSA clearance from wound infections. Catestatin (mouse) dampens the inflammatory immune response to MRSA infection.