2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Prolyl Endopeptidase (PREP)

Prolyl Endopeptidase (PREP)

prolyl oligopeptidase; POP

Prolyl endopeptidase (PREP), also known as prolyl oligopeptidase (POP), a member of the serine protease family, which can specifically hydrolyze the peptide bond of the carboxylterminus of the proline residue in the polypeptide chain, has high activity in the liver. Accumulated evidence suggests that PREP participates in physiological and pathological processes, including maturation and degradation of peptides, inflammation, oxidative stress, autophagy, cell proliferation and cancer.

Prolyl Endopeptidase (PREP) Related Products (55):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-15116
    ONO 1603
    		Inhibitor
    ONO 1603, a novel prolyl endopeptidase inhibitor investigated as a potential antidementia drug, demonstrated neuroprotective and neurotrophic effects in cerebellar granule cells similar to tetrahydroaminoacridine (THA). At a concentration of 0.03 microM, ONO 1603 promoted neuronal survival, enhanced neurite outgrowth, increased m3-muscarinic acetylcholine receptor (mAChR) mRNA levels, and stimulated mAChR-mediated signaling pathways. These findings suggest that ONO 1603 shares pharmacological similarities with THA, indicating its potential as a therapeutic agent for Alzheimer's disease by enhancing cholinergic neurotransmission and neuronal function.
    ONO 1603
  • HY-125432
    Poststatin
    		Inhibitor
    Poststatin is a pecific prolyl endopeptidase (PEP) inhibitor. Poststatin inhibits bradykinin-degrading enzymes in rat urine.
    Poststatin
  • HY-15115
    SUAM 1221
    		Inhibitor
    SUAM 1221 is a prolyl endopeptidase inhibitor. CS-0777 can be used in the research of Alzheimer diseases.
    SUAM 1221
  • HY-100684R
    UAMC-1110 (Standard)
    		Inhibitor
    UAMC-1110 (Standard) is the analytical standard of UAMC-1110 (HY-100684). This product is intended for research and analytical applications. UAMC-1110 is a highly potent and selective inhibitor of fibroblast activation protein (FAP) with an IC50 of 3.2 nM. UAMC-1110 also inhibits prolyl oligopeptidase (PREP) with an IC50 of 1.8 μM.
    UAMC-1110 (Standard)
  • HY-17455R
    Pramiracetam (Standard)
    		Inhibitor
    Pramiracetam (Standard) is the analytical standard of Pramiracetam. This product is intended for research and analytical applications. Pramiracetam (CI-879 free base) is a PREP (prolyl endopeptidase) inhibitor. Pramiracetam improves cognitive impairment caused by traumatic brain injury. Pramiracetam can be used in the study of neurodegenerative diseases.
    Pramiracetam (Standard)
  • HY-N2481R
    Oroxylin A-7-O-glucuronide (Standard)
    		Inhibitor
    Oroxylin A-7-O-glucuronide (Standard) is the analytical standard of Oroxylin A-7-O-glucuronide (HY-N2481). This product is intended for research and analytical applications. Oroxylin A-7-O-glucuronide (oroxyloside) is an orally active flavonoid glucuronide and metabolite of Oroxylin A (HY-N0560). Oroxylin A-7-O-glucuronide can be extracted from the dried root of Scutellaria baicalensis. Oroxylin A-7-O-glucuronide exhibits prolyl oligopeptidase inhibitory activity. Oroxylin A-7-O-glucuronide inhibits the JNK pathway, upregulates PPARγ, and inhibits NF-κB p65 nuclear translocation. Oroxylin A-7-O-glucuronide reduces cytokine (IL-1β, IL-6) production. Oroxylin A-7-O-glucuronide exhibits anti-angiogenic, anti-tumor (glioma, liver cancer), anti-inflammatory, and hepatoprotective activities.
    Oroxylin A-7-O-glucuronide (Standard)
  • HY-N15009
    Kynapcin-13
    		Inhibitor
    Kynapcin-13 can non-competitively inhibit the activity of prolyl endopeptidase (PEP) with an IC50 of 76.80 μM. Kynapcin-13 has a little inhibitory effect on other serine proteases.
    Kynapcin-13
  • HY-N15070
    Polyozellin
    		Inhibitor
    Polyozellin is a prolyl endopeptidase inhibitor. Polyozellin has activities against inflammation, cancer, and oxidative stress-related disorders. .
    Polyozellin
  • HY-N15010
    Kynapcin-28
    		Inhibitor
    Kynapcin-28 can non-competitively inhibit the activity of prolyl endopeptidase (PEP) with an IC50 of 76.80 μM. Kynapcin-28 has a little inhibitory effect on other serine proteases.
    Kynapcin-28
  • HY-N5194
    Lipohexin
    		Inhibitor
    Lipohexin is a peptide antibiotic. Lipohexin has anti-Gram-positive bacterial effect. Lipohexin had competitive inhibitory effect on human placental proline endopeptidase with an IC50 of 3.5 μM. Lipohexin inhibits the proline endopeptidase from the Flavobacterium meningoseptiu with an IC50 of 25 μM.
    Lipohexin
  • HY-N14218
    Eurystatin A
    		Inhibitor
    Eurystatin A is a prolyl endopeptidase inhibitor, L-Leucine and L-Ornithine are the direct precursors of the L-Leucine and L-Ornithine moieties of eurystatins A.
    Eurystatin A
  • HY-181070
    PREP-IN-2
    		Inhibitor
    PREP-IN-2 is an irreversible and selective prolyl endopeptidase (PREP) inhibitor with an IC50 of 0.53 μM and a Ki of 0.62 μM. PREP-IN-2 can be used in research related to neurodegenerative diseases and triple-negative breast cancer.
    PREP-IN-2
  • HY-N14226
    Eurystatin B
    		Inhibitor
    Eurystatin B is a prolyl endopeptidase (PED) inhibitor. Eurystatin B has a protective effect during Scopolamine (HY-N0296)-induced amnesia in rats.
    Eurystatin B
  • HY-100475R
    KYP-2047 (Standard)
    		Inhibitor
    KYP-2047 (Standard) is the analytical standard of KYP-2047 (HY-100475). This product is intended for research and analytical applications. KYP-2047 is a potent and BBB-penetrating prolyl-oligopeptidase (POP) inhibitor, with an Ki value of 0.023 nM. KYP-2047 reduces glioblastoma proliferation through angiogenesis and apoptosis modulation.
    KYP-2047 (Standard)
  • HY-107758
    Y-29794 oxalate
    		Inhibitor
    Y-29794 oxalate is a selective, orally active and blood-brain barrier permeable non-peptide prolyl endopeptidase inhibitor. Y-29794 oxalate blocks the IRS1-AKT-mTORC1 pathway and inhibits tumor growth. Y-29794 oxalate is also effective in inhibiting the progression of Aβ-like deposition in the hippocampus of aging-accelerated mice (SAM).
    Y-29794 oxalate