Prolyl Endopeptidase (PREP)
prolyl oligopeptidase; POP
Prolyl endopeptidase (PREP), also known as prolyl oligopeptidase (POP), a member of the serine protease family, which can specifically hydrolyze the peptide bond of the carboxylterminus of the proline residue in the polypeptide chain, has high activity in the liver. Accumulated evidence suggests that PREP participates in physiological and pathological processes, including maturation and degradation of peptides, inflammation, oxidative stress, autophagy, cell proliferation and cancer.
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Prolyl Endopeptidase (PREP) Related Products (56)
Related Products (56)
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Y-29794 tosylate
0 ImagesY-29794 tosylate is a selective, orally active inhibitor for non-peptide prolyl endopeptidase (PREP), with an IC50 of 3 nM and a Ki of 0.95 nM. Y-29794 tosylate enhances the effect of thyrotropin-releasing hormone (TRH) on the release of ACh in the rat hippocampus, exhibits potential neuroprotective efficacy. Y-29794 tosylate exhibits anticancer activity through inhibition of the IRS1-AKT-mTORC1 pathway. Y-29794 tosylate penetrates the brain-blood barrier (BBB).
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RB 101
0 ImagesCat. No.: HY-117702CAS No.: 135949-60-9RB 101 is a blood-brain barrier-crossing prodrug as well as aminopeptidase N and neutral endopeptidase-24.11 inhibitor. RB 101 blocks enkephalin breakdown, elevates extracellular enkephalin levels and activate δ-opioid receptor and dopamine D1 receptor. RB 101 can be used for the research of pain, depressive syndromes, and diabetic neuropathy.
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Prolylisoleucine
0 ImagesProlylisoleucine (Pro-Ile) is a dipeptide composed of Proline and Isoleucine, as well as a blocker of endopeptidase 24.16.
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Z-Pro-prolinal
0 ImagesSynonyms: N-Benzyloxycarbonyl-L-prolyl-L-prolinalZ-Pro-prolinal (N-Benzyloxycarbonyl-L-prolyl-L-prolinal) is a specific, orally active prolyl endopeptidase (PREP) inhibitor with an IC50 of 0.4 nM for porcine PREP.
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β-Elemonic acid (Standard)
0 ImagesCat. No.: HY-N2454RCAS No.: 28282-25-9β-Elemonic acid (Standard) is the analytical standard of β-Elemonic acid. This product is intended for research and analytical applications. β-Elemonic acid is a triterpene isolated from Boswellia carterii. β-Elemonic acid induces cell apoptosis, reactive oxygen species (ROS) and COX-2 expression and inhibits prolyl endopeptidase. β-Elemonic acid exhibits anticancer and anti-inflammatory effects.
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Pramiracetam sulfate
0 ImagesCat. No.: HY-W001273CAS No.: 72869-16-0Synonyms: CI-879 sulfatePramiracetam (CI-879) sulfate Pramiracetam is a PREP (prolyl endopeptidase) inhibitor. Pramiracetam sulfate improves cognitive impairment caused by traumatic brain injury. Pramiracetam sulfate can be used in the study of neurodegenerative diseases.
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Pyrrocidine B
0 ImagesCat. No.: HY-N16442CAS No.: 428439-25-2Pyrrocidine B (Compound 6), an alkaloid, is a microbial secondary metabolite. Pyrrocidine B can be isolated from the endophytic fungus Neonectria ramulariae Wollenw KS-246. Pyrrocidine B has significant cytotoxicity against leukemia cells (IC50 of 4.6 μM for HL60 cells) with a weak Prolyl oligopeptidase (POP) inhibitory activity.
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POP-IN-2
0 ImagesCat. No.: HY-143475CAS No.: 2743432-81-5POP-IN-2 (Compound 7k) is a potent, covalent prolyl oligopeptidase (POP) inhibitor with a Ki of 6 nM. POP-IN-2 can be used for studying neurodegenerative diseases and cancer.
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Y-29794
0 ImagesCat. No.: HY-15113CAS No.: 129184-48-1Y-29794 is a selective, orally active inhibitor for non-peptide prolyl endopeptidase (PREP), with an IC50 of 3 nM and a Ki of 0.95 nM. Y-29794 enhances the effect of thyrotropin-releasing hormone (TRH) on the release of ACh in the rat hippocampus, exhibits potential neuroprotective efficacy. Y-29794 exhibits anticancer activity through inhibition of the IRS1-AKT-mTORC1 pathway. Y-29794 penetrates the brain-blood barrier (BBB).
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Z-Thioprolyl-Thiazolidine
0 ImagesCat. No.: HY-148332CAS No.: 118059-38-4Z-Thioprolyl-Thiazolidine is a potent and specific prolyl endopeptidase inhibitor with an Ki value of 0.36 nM for bovine brain prolyl endopeptidase
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POP-IN-1
0 ImagesCat. No.: HY-146667CAS No.: 2743432-99-5POP-IN-1 (Compound 12h) is a potent inhibitor of POP with an Ki of 0.009 μM. POP-IN-1 has the potential for the research of neurodegenerative diseases and cancer progression.
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Z-Pro-Pro-aldehyde-dimethyl acetal
0 ImagesCat. No.: HY-P4308CAS No.: 170116-63-9Z-Pro-Pro-aldehyde-dimethyl acetal is a potent inhibitor of prolyl endopeptidase (PREP), a cytoplasmic serine endoprotease (IC50= 12 nM). Z-Pro-Pro-aldehyde-dimethyl acetal plays an important role in cognitive dysfunction in aging and neurodegenerative diseases including Alzheimer's disease.
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CGS 24592
0 ImagesCat. No.: HY-171461CAS No.: 147923-04-4CGS 24592 is an orally active, selective and potent neutral endopeptidase 24.11 (NEP) inhibitor with an IC50 value of 1.6 nmol/L. CGS 24592 reduces the degradation of atrial natriuretic peptide (ANP), increases the concentration of ANP in the plasma, and reduces blood pressure. CGS 24592 is promising for research of cardiovascular disease, such as hypertension and congestive heart failure.
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SCH-39370
0 ImagesCat. No.: HY-139803CAS No.: 115406-23-0SCH-39370 is a potent and specific inhibitor of neutral metalloendopeptidase (NEP) from rabbit kidney with an IC50 value of 11.2 nM. SCH-39370 potentiates biological responses to atrial natriuretic factor and lowers blood pressure in desoxycorticosterone acetate-sodium hypertensive rats.
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Linderene acetate
0 ImagesLinderene acetate, isolated from the root of Lindera strychnifolia, is a prolyl endopeptidase inhibitor.
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Ala-Ala-βNA
0 ImagesCat. No.: HY-P4527CAS No.: 20724-07-6Ala-Ala-βNA is a dipeptidyl-fl-naphthylamide (βNA). Ala-Ala-βNA is readily hydrolyzed, with optimum hydrolysis pH of 8.5-9.0.
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ARI-3531
0 ImagesCat. No.: HY-116828CAS No.: 1432499-51-8ARI-3531 (compound 22) is a selective prolyl oligopeptidase (PREP) inhibitor (Ki=0.73 nM). ARI-3531 can be used to study tumor invasion and metastasis.
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Z-Thioprolyl-Thioproline
0 ImagesCat. No.: HY-148331CAS No.: 118059-40-8Z-Thioprolyl-Thioproline is a bovine brain prolyl endopeptidase (PEP) inhibitor (IC50=16 µM; Ki=37 µM). Z-Thioprolyl-Thioproline is used in the study of neurological disorders such as memory disorders and cognitive disorders.
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POP-IN-3
0 ImagesCat. No.: HY-143474CAS No.: 2554621-98-4Y-29794 (Compound 2) is a potent, covalent prolyl oligopeptidase (POP) inhibitor with a Ki of 0.95 nM. Y-29794 can be used for studying neurodegenerative diseases and cancer.
