2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Prolyl Endopeptidase (PREP)

Prolyl Endopeptidase (PREP)

prolyl oligopeptidase; POP

Prolyl endopeptidase (PREP), also known as prolyl oligopeptidase (POP), a member of the serine protease family, which can specifically hydrolyze the peptide bond of the carboxylterminus of the proline residue in the polypeptide chain, has high activity in the liver. Accumulated evidence suggests that PREP participates in physiological and pathological processes, including maturation and degradation of peptides, inflammation, oxidative stress, autophagy, cell proliferation and cancer.

Prolyl Endopeptidase (PREP) Related Products (55):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-117702
    RB 101
    		Inhibitor
    RB 101 is a blood-brain barrier-crossing prodrug as well as aminopeptidase N and neutral endopeptidase-24.11 inhibitor. RB 101 blocks enkephalin breakdown, elevates extracellular enkephalin levels and activate δ-opioid receptor and dopamine D1 receptor. RB 101 can be used for the research of pain, depressive syndromes, and diabetic neuropathy.
    RB 101
  • HY-124005
    Prolylisoleucine
    		Inhibitor 98.0%
    Prolylisoleucine (Pro-Ile) is a dipeptide composed of Proline and Isoleucine, as well as a blocker of endopeptidase 24.16.
    Prolylisoleucine
  • HY-134454A
    Z-Pro-prolinal
    		Inhibitor
    Z-Pro-prolinal (N-Benzyloxycarbonyl-L-prolyl-L-prolinal) is a specific, orally active prolyl endopeptidase (PREP) inhibitor with an IC50 of 0.4 nM for porcine PREP.
    Z-Pro-prolinal
  • HY-N2454R
    β-Elemonic acid (Standard)
    		Inhibitor
    β-Elemonic acid (Standard) is the analytical standard of β-Elemonic acid. This product is intended for research and analytical applications. β-Elemonic acid is a triterpene isolated from Boswellia carterii. β-Elemonic acid induces cell apoptosis, reactive oxygen species (ROS) and COX-2 expression and inhibits prolyl endopeptidase. β-Elemonic acid exhibits anticancer and anti-inflammatory effects.
    β-Elemonic acid (Standard)
  • HY-W001273
    Pramiracetam sulfate
    		Inhibitor
    Pramiracetam (CI-879) sulfate Pramiracetam is a PREP (prolyl endopeptidase) inhibitor. Pramiracetam sulfate improves cognitive impairment caused by traumatic brain injury. Pramiracetam sulfate can be used in the study of neurodegenerative diseases.
    Pramiracetam sulfate
  • HY-N16442
    Pyrrocidine B
    		Inhibitor
    Pyrrocidine B (Compound 6), an alkaloid, is a microbial secondary metabolite. Pyrrocidine B can be isolated from the endophytic fungus Neonectria ramulariae Wollenw KS-246. Pyrrocidine B has significant cytotoxicity against leukemia cells (IC50 of 4.6  μM for HL60 cells) with a weak Prolyl oligopeptidase (POP) inhibitory activity.
    Pyrrocidine B
  • HY-143475
    POP-IN-2
    		Inhibitor
    POP-IN-2 (Compound 7k) is a potent, covalent prolyl oligopeptidase (POP) inhibitor with a Ki of 6 nM. POP-IN-2 can be used for studying neurodegenerative diseases and cancer.
    POP-IN-2
  • HY-15113
    Y-29794
    		Inhibitor
    Y-29794 is a selective, orally active inhibitor for non-peptide prolyl endopeptidase (PREP), with an IC50 of 3 nM and a Ki of 0.95 nM. Y-29794 enhances the effect of thyrotropin-releasing hormone (TRH) on the release of ACh in the rat hippocampus, exhibits potential neuroprotective efficacy. Y-29794 exhibits anticancer activity through inhibition of the IRS1-AKT-mTORC1 pathway. Y-29794 penetrates the brain-blood barrier (BBB).
    Y-29794
  • HY-148332
    Z-Thioprolyl-Thiazolidine
    		Inhibitor
    Z-Thioprolyl-Thiazolidine is a potent and specific prolyl endopeptidase inhibitor with an Ki value of 0.36 nM for bovine brain prolyl endopeptidase
    Z-Thioprolyl-Thiazolidine
  • HY-146667
    POP-IN-1
    		Inhibitor
    POP-IN-1 (Compound 12h) is a potent inhibitor of POP with an Ki of 0.009 μM. POP-IN-1 has the potential for the research of neurodegenerative diseases and cancer progression.
    POP-IN-1
  • HY-P4308
    Z-Pro-Pro-aldehyde-dimethyl acetal
    		Inhibitor
    Z-Pro-Pro-aldehyde-dimethyl acetal is a potent inhibitor of prolyl endopeptidase (PREP), a cytoplasmic serine endoprotease (IC50= 12 nM). Z-Pro-Pro-aldehyde-dimethyl acetal plays an important role in cognitive dysfunction in aging and neurodegenerative diseases including Alzheimer's disease.
    Z-Pro-Pro-aldehyde-dimethyl acetal
  • HY-171461
    CGS 24592
    		Inhibitor
    CGS 24592 is an orally active, selective and potent neutral endopeptidase 24.11 (NEP) inhibitor with an IC50 value of 1.6 nmol/L. CGS 24592 reduces the degradation of atrial natriuretic peptide (ANP), increases the concentration of ANP in the plasma, and reduces blood pressure. CGS 24592 is promising for research of cardiovascular disease, such as hypertension and congestive heart failure.
    CGS 24592
  • HY-178981
    FAP-IN-8
    		Inhibitor
    FAP-IN-8 (Compound 12i) is a potent inhibitor of PREP and FAP, with pIC50 values ​​of 8.99 and 10.08 for FAP and PREP, and IC50 values ​​of 1 and 0.08 nM, respectively. FAP-IN-8 may be used in cancer research.
    FAP-IN-8
  • HY-139803
    SCH-39370
    		Inhibitor
    SCH-39370 is a potent and specific inhibitor of neutral metalloendopeptidase (NEP) from rabbit kidney with an IC50 value of 11.2 nM. SCH-39370 potentiates biological responses to atrial natriuretic factor and lowers blood pressure in desoxycorticosterone acetate-sodium hypertensive rats.
    SCH-39370
  • HY-N6902
    Linderene acetate
    		Inhibitor 99.31%
    Linderene acetate, isolated from the root of Lindera strychnifolia, is a prolyl endopeptidase inhibitor.
    Linderene acetate
  • HY-P4527
    Ala-Ala-βNA
    Ala-Ala-βNA is a dipeptidyl-fl-naphthylamide (βNA). Ala-Ala-βNA is readily hydrolyzed, with optimum hydrolysis pH of 8.5-9.0.
    Ala-Ala-βNA
  • HY-116828
    ARI-3531
    		Inhibitor
    ARI-3531 (compound 22) is a selective prolyl oligopeptidase (PREP) inhibitor (Ki=0.73 nM). ARI-3531 can be used to study tumor invasion and metastasis.
    ARI-3531
  • HY-148331
    Z-Thioprolyl-Thioproline
    		Inhibitor
    Z-Thioprolyl-Thioproline is a bovine brain prolyl endopeptidase (PEP) inhibitor (IC50=16 µM; Ki=37 µM). Z-Thioprolyl-Thioproline is used in the study of neurological disorders such as memory disorders and cognitive disorders.
    Z-Thioprolyl-Thioproline
  • HY-143474
    POP-IN-3
    		Inhibitor
    Y-29794 (Compound 2) is a potent, covalent prolyl oligopeptidase (POP) inhibitor with a Ki of 0.95 nM. Y-29794 can be used for studying neurodegenerative diseases and cancer.
    POP-IN-3
  • HY-15112
    JTP-4819
    		Inhibitor
    JTP-4819 is a potent and specific inhibitor of prolyl endopeptidase (PREP) with IC50s of 0.83 nM (in rat brain supernatant) and 5.43 nM (in Flavobacterium meningosepticum). JTP-4819 has blood-brain penetration, also improves the retention time of amnesia rats induced by Scopolamine (HY-N2096).
    JTP-4819