796874-99-2
796874-99-2
Chemical Structure
KYP-2047
- CAS No.: 796874-99-2
- Formula:C20H25N3O2
- Molecular Weight:339.43
IUPAC Name: (S)-1-((4-phenylbutanoyl)-L-prolyl)pyrrolidine-2-carbonitrile
InChIKey: SPXFAUXQZWJGCJ-ROUUACIJSA-N
SMILES: N#C[C@H]1N(C([C@H]2N(C(CCCC3=CC=CC=C3)=O)CCC2)=O)CCC1
Biological Activity: KYP-2047 is a potent and BBB-penetrating prolyl-oligopeptidase (POP) inhibitor, with an Ki value of 0.023 nM. KYP-2047 reduces glioblastoma proliferation through angiogenesis and apoptosis modulation[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KYP-2047 | 99.94% | KYP-2047 is a potent and BBB-penetrating prolyl-oligopeptidase (POP) inhibitor, with an Ki value of 0.023 nM. KYP-2047 reduces glioblastoma proliferation through angiogenesis and apoptosis modulation. | ||||||||||||||||||||
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KYP-2047 (Standard) | ≥98% | KYP-2047 (Standard) is the analytical standard of KYP-2047 (HY-100475). This product is intended for research and analytical applications. KYP-2047 is a potent and BBB-penetrating prolyl-oligopeptidase (POP) inhibitor, with an Ki value of 0.023 nM. KYP-2047 reduces glioblastoma proliferation through angiogenesis and apoptosis modulation. | ||||||||||||||||||||
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References
- [1]. Jalkanen AJ, et al. Beneficial effect of prolyl oligopeptidase inhibition on spatial memory in young but not in old scopolamine-treated rats. Basic Clin Pharmacol Toxicol. 2007 Feb;100(2):132-8. [Content Brief]
- [2]. Scuderi SA, et al. KYP-2047, an Inhibitor of Prolyl-Oligopeptidase, Reduces GlioBlastoma Proliferation through Angiogenesis and Apoptosis Modulation. Cancers (Basel). 2021 Jul 9;13(14):3444. [Content Brief]
Keywords
