2. Signaling Pathways
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  4. Reference Standards

Reference Standards

Material, sufficiently homogeneous and stable with respect to one or more specified properties, and the uses include the calibration of a measurement system, assessment of a measurement procedure, assigning values to other materials, and quality control and so on.

Reference Standards Related Products (10970):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0153AR
    Ticlopidine hydrochloride (Standard)
    Ticlopidine hydrochloride (Standard) is the analytical standard of Ticlopidine hydrochloride (HY-B0153A). This product is intended for research and analytical applications. Ticlopidine (PCR 5332) hydrochloride, an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC50 of 81.7 μM. Ticlopidine hydrochloride blocks several NTPDase isoenzymes with IC50s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively. Ticlopidine hydrochloride is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine hydrochloride inhibits CYP2C9 and CYP3A4 with IC50s of 26.0 and 32.3 μM, respectively.
    Ticlopidine hydrochloride (Standard)
  • HY-103347R
    M50054 (Standard)
    M50054 (Standard) is the analytical standard of M50054. This product is intended for research and analytical applications. M50054 is a potent inhibitor of apoptosis. M50054 inhibits Etoposide-induced caspase-3 activation of U937 cells with an IC50 of 79 μg/mL. M50054 does not directly inhibit the enzymatic activity of caspase-3. M50054 can be used for the research anti-Fas-antibody-induced hepatitis and chemotherapy-induced alopecia.
    M50054 (Standard)
  • HY-W002549R
    4-Amino-3,5-dibromopyridine (Standard)
    4-Amino-3,5-dibromopyridine (Standard) is the analytical standard of 4-Amino-3,5-dibromopyridine. This product is intended for research and analytical applications.
    4-Amino-3,5-dibromopyridine (Standard)
  • HY-W008437R
    (S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid dihydrate (Standard)
    (S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid dihydrate (Standard) is the analytical standard of (S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid dihydrate (HY-W008437). This product is intended for research and analytical applications. (S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid dihydrate is an endogenous metabolite.
    (S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid dihydrate (Standard)
  • HY-W002343R
    3,5-Dimethylbenzaldehyde (Standard)
    3,5-Dimethylbenzaldehyde (Standard) is the analytical standard of 3,5-Dimethylbenzaldehyde (HY-W002343). This product is intended for research and analytical applications. 3,5-Dimethylbenzaldehyde is a building block in the chemical synthesis.
    3,5-Dimethylbenzaldehyde (Standard)
  • HY-N0699R
    Daphnoretin (Standard)
    Daphnoretin (Dephnoretin; Thymelol) (Standard) is the analytical standard of Daphnoretin (HY-N0699). This product is used for research and analytical applications. Daphnoretin is a protein kinase C (PKC) activator that can inhibit the expression of hepatitis B virus (HBV) surface antigen (HBsAg) and has antiviral activity. Daphnoretin exerts its anti-tumor effect by inhibiting the activation of the PI3K/AKT signaling pathway, triggering the mitochondrial apoptosis pathway. Daphnoretin alleviates chondrocyte apoptosis and inflammatory responses by inhibiting endoplasmic reticulum stress and the activation of the NLRP3 inflammasome. Daphnoretin can regulate the differentiation and maturation of dendritic cells, by down-regulating the phosphorylation level of JNK, inhibiting its immune stimulating function, thereby playing a protective role in skin transplant rejection reactions.
    Daphnoretin (Standard)
  • HY-10336R
    Brivanib (alaninate) (Standard)
    Brivanib (alaninate) (Standard) is the analytical standard of Brivanib (alaninate). This product is intended for research and analytical applications. Brivanib alaninate (BMS-582664) is an ATP-competitive inhibitor against VEGFR2 with an IC50 of 25 nM; has moderate potency against VEGFR-1 and FGFR-1, but more than 240-fold against PDGFRβ.
    Brivanib (alaninate) (Standard)
  • HY-100687R
    GNF-PF-3777 (Standard)
    GNF-PF-3777 (Standard) is the analytical standard of GNF-PF-3777 (HY-100687). This product is intended for research and analytical applications. GNF-PF-3777 (8-Nitrotryptanthrin) is a potent human indoleamine 2,3-dioxygenase 2 (hIDO2) inhibitor which significantly reduces IDO2 activity with Ki of 0.97 μM.
    GNF-PF-3777 (Standard)
  • HY-W150287R
    2,2'-(1,4-Phenylene)bis-4H-3,1-benzoxazin-4-one (Standard)
    2,2'-(1,4-Phenylene)bis-4H-3,1-benzoxazin-4-one (Standard) is the analytical standard of 2,2'-(1,4-Phenylene)bis-4H-3,1-benzoxazin-4-one. This product is intended for research and analytical applications.
    2,2'-(1,4-Phenylene)bis-4H-3,1-benzoxazin-4-one (Standard)
  • HY-13243R
    Alvimopan (Standard)
    Alvimopan (Standard) is the analytical standard of Alvimopan. This product is intended for research and analytical applications. Alvimopan (ADL 8-2698) is a potent, selective, orally active and reversible μ-opioid receptor antagonist, with an IC50 of 1.7 nM. Alvimopan has selectivity for μ-opioid receptor (Ki=0.47 nM) over κ- and δ-opioid receptors (Kis=100, 12 nM, respectively). Alvimopan can be used for the research of postoperative ileus.
    Alvimopan (Standard)
  • HY-B0842R
    Thiophanate-Methyl (Standard)
    Thiophanate-Methyl (Standard) is the analytical standard of Thiophanate-Methyl. This product is intended for research and analytical applications. Thiophanate-Methyl is a systematic fungicide.
    Thiophanate-Methyl (Standard)
  • HY-W270328R
    5-Vinylpyrrolidin-2-one (Standard)
    5-Vinylpyrrolidin-2-one,98%(stabilized with TBC) (Standard) is the analytical standard of 5-Vinylpyrrolidin-2-one,98%(stabilized with TBC). This product is intended for research and analytical applications.
    5-Vinylpyrrolidin-2-one (Standard)
  • HY-100233R
    IQ-1S free acid (Standard)
    IQ-1S (free acid) (Standard) is the analytical standard of IQ-1S (free acid) (HY-100233). This product is intended for research and analytical applications. IQ-1S free acid is a prospective inhibitor of NF-κB/activating protein 1 (AP-1) activity with an IC50 of 2.3±0.41 μM. IQ-1S free acid has binding affinity (Kd values) in the nanomolar range for all three JNKs with Kds of 100 nM, 240 nM, and 360 nM for JNK3, JNK1, and JNK2, respectively.
    IQ-1S free acid (Standard)
  • HY-10835R
    DG-041 (Standard)
    DG-041 (Standard) is the analytical standard of DG-041 (HY-10835). This product is intended for research and analytical applications. DG-041 is a potent, high affinity and selective EP3 receptor antagonist with IC50s of 4.6 nM and 8.1 nM in the binding and FLIPR assay, respectively. DG-041 inhibits PGE2 facilitation of platelet aggregation. DG-041 crosses the blood-brain barrier.
    DG-041 (Standard)
  • HY-100726R
    GNE-272 (Standard)
    GNE-272 (Standard) is the analytical standard of GNE-272 (HY-100726). This product is intended for research and analytical applications. GNE-272 is a potent and selective CBP/EP300 inhibitor with IC50 values of 0.02, 0.03 and 13 μM for CBP, EP300 and BRD4, respectively. GNE-272 is also a selective in vivo probe for CBP/EP300.
    GNE-272 (Standard)
  • HY-10558R
    CYC-116 (Standard)
    CYC-116 (Standard) is the analytical standard of CYC-116 (HY-10558). This product is intended for research and analytical applications. CYC-116 is a potent aurora A and aurora B inhibitor with Kis of 8 and 9 nM, respectively.
    CYC-116 (Standard)
  • HY-12740R
    Lotamilast (Standard)
    Lotamilast (Standard) is the analytical standard of Lotamilast. This product is intended for research and analytical applications. Lotamilast (RVT-501; E6005) is a selective phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 2.8 nM.
    Lotamilast (Standard)
  • HY-10405R
    Pamapimod (Standard)
    Pamapimod (Standard) is the analytical standard of Pamapimod. This product is intended for research and analytical applications. Pamapimod (Ro4402257) is a potent, selective and orally active p38 MAPK inhibitor with IC50s of 14 nM and 480 nM and Kis of 1.3 nM and 120 nM for p38α and p38β, respectively. Pamapimod has no activity against p38δ or p38γ isoforms. Pamapimod has the potential for rheumatoid arthritis and other autoimmune diseases treatment.
    Pamapimod (Standard)
  • HY-B0455R
    Lomefloxacin hydrochloride (Standard)
    Lomefloxacin (hydrochloride) (Standard) is the analytical standard of Lomefloxacin hydrochloride (HY-B0455). This product is intended for research and analytical applications. Lomefloxacin hydrochloride (NY-198 hydrochloride) is an orally active difluoroquinolone antibiotic. Lomefloxacin hydrochloride prevents DNA supercoiling and replication by inhibiting bacterial topoisomerase II. Lomefloxacin hydrochloride induces ROS production and Apoptosis. Lomefloxacin hydrochloride has broad-spectrum bactericidal activity against Gram-positive and Gram-negative bacteria. Lomefloxacin hydrochloride has anticancer effects against melanoma. Lomefloxacin hydrochloride can be used in the study of systemic bacterial infections (such as Salmonella typhimurium infections), skin and melanoma .
    Lomefloxacin hydrochloride (Standard)
  • HY-10237R
    Boceprevir (Standard)
    Boceprevir (Standard) is the analytical standard of Boceprevir. This product is intended for research and analytical applications. Boceprevir (EBP 520) is a potent, highly selective, orally bioavailable HCV NS3 protease inhibitor with a Ki of 14 nM in both enzyme assay and an EC90 of 350 nM in cell-based replicon assay. Boceprevir inhibits SARS-CoV-2 3CLpro activity.
    Boceprevir (Standard)