1689-89-0
Chemical Structure
Nitroxynil
- CAS No.: 1689-89-0
- Formula:C7H3IN2O3
- Molecular Weight:290.02
IUPAC Name: 4-hydroxy-3-iodo-5-nitrobenzonitrile
InChIKey: SGKGVABHDAQAJO-UHFFFAOYSA-N
SMILES: N#CC1=CC([N+]([O-])=O)=C(O)C(I)=C1
Biological Activity: Nitroxynil is a broad-spectrum veterinary anthelmintic and a substrate of ABCG2. Nitroxynil inhibits ATP production by uncoupling the oxidative phosphorylation process of mitochondria, thereby disrupting the parasite body covering, impairing its motility, and ultimately inducing parasite death. Nitroxynil induces chromosomal aberrations, sister chromatid exchanges and abnormal sperm morphology, and interferes with spermatogenesis. Nitroxynil is widely applicable to studies on fascioliasis, myiasis, Haemonchus spp. infections, and Oestrus ovis infections[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Nitroxynil | 98.92% | Nitroxynil is a broad-spectrum veterinary anthelmintic and a substrate of ABCG2. Nitroxynil inhibits ATP production by uncoupling the oxidative phosphorylation process of mitochondria, thereby disrupting the parasite body covering, impairing its motility, and ultimately inducing parasite death. Nitroxynil induces chromosomal aberrations, sister chromatid exchanges and abnormal sperm morphology, and interferes with spermatogenesis. Nitroxynil is widely applicable to studies on fascioliasis, myiasis, Haemonchus spp. infections, and Oestrus ovis infections. | ||||||||||||||||||||
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Nitroxynil (Standard) | ≥98% | Nitroxynil (Standard) is the analytical standard of Nitroxynil. This product is intended for research and analytical applications. Nitroxynil, anthelmintic agent, is active against parasites in both adult and immature stages. Nitroxynil is widely used for the research of infection of Fasciola hepatica. | ||||||||||||||||||||
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- [1]. Álvarez-Fernández L, et al. ABCG2 Transports the Flukicide Nitroxynil and Affects Its Biodistribution and Secretion into Milk. Pharmaceutics. 2024 Apr 19;16(4):558. [Content Brief]
- [2]. Rahman M M, et al. Nitroxynil uncouples oxidative phosphorylation in the cell mitochondria and a drug wherever injectables are preferred over drenches[J]. Bangladesh Journal of Veterinary Medicine, 2017, 15(1): 45-49.
- [3]. Donya S M, et al. Clastogenic Effects of the Fasciolicides Closantel and Nitroxynil on Mice Somatic and Germ Cells[J]. Cytologia, 2007, 72(1): 29-36.
Keywords
