Aβ aggregation-IN-6
Aβ aggregation-IN-6 is an Aβ aggregation inhibitor with ~60-70% inhibition of Aβ17-40 aggregation. Aβ aggregation-IN-6 stabilizes Aβ dimer assembly, binds to Aβ steric-zipper assembly. Aβ aggregation-IN-6 can be used for the research of alzheimer's disease.
For research use only. We do not sell to patients.
- CAS No.: 439932-74-8
- Formula: C15H16Cl2N2O2S2
- Molecular Weight:391.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Aβ aggregation-IN-6 (compound 4) stabilizes the Aβ dimer assembly via multiple polar and nonpolar interactions, with a CDOCKER interaction energy of -18.93 kcal/mol, to inhibit further Aβ aggregation[1].
Aβ aggregation-IN-6 (compound 4) binds to the Aβ steric-zipper assembly via multiple favorable interactions, with a CDOCKER interaction energy of -30.48 kcal/mol, to stabilize the assembly and reduce Aβ aggregate cytotoxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 439932-74-8
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Molecular Weight 391.33
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Formula C15H16Cl2N2O2S2
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SMILES
O=S(=O)(NC1=CC=C(C=C1)N2CCCCC2)C=3C=C(Cl)SC3Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Aβ aggregation-IN-6 Related Classifications
HY-123745 Related Classifications
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