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Art. -Nr.: HY-123745

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Aβ aggregation-IN-6

Aβ aggregation-IN-6 is an Aβ aggregation inhibitor with ~60-70% inhibition of Aβ_17-40 aggregation. Aβ aggregation-IN-6 stabilizes Aβ dimer assembly, binds to Aβ steric-zipper assembly. Aβ aggregation-IN-6 can be used for the research of alzheimer's disease.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 439932-74-8
Formel: C₁₅H₁₆Cl₂N₂O₂S₂
Molecular Weight:391.33

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Aβ aggregation-IN-6 Chemical Structure

CAS. Nr.: 439932-74-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Aβ aggregation-IN-6 (compound 4) stabilizes the Aβ dimer assembly via multiple polar and nonpolar interactions, with a CDOCKER interaction energy of -18.93 kcal/mol, to inhibit further Aβ aggregation^[1].
Aβ aggregation-IN-6 (compound 4) binds to the Aβ steric-zipper assembly via multiple favorable interactions, with a CDOCKER interaction energy of -30.48 kcal/mol, to stabilize the assembly and reduce Aβ aggregate cytotoxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Alzheimer’s Disease Modeling

Chemical Information

CAS. Nr. 439932-74-8
Molecular Weight 391.33
Formel C₁₅H₁₆Cl₂N₂O₂S₂
SMILES

O=S(=O)(NC1=CC=C(C=C1)N2CCCCC2)C=3C=C(Cl)SC3Cl
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Mohamed T, et al. Amyloid cascade in Alzheimer's disease: Recent advances in medicinal chemistry. Eur J Med Chem. 2016;113:258-272. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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