1. Metabolic Enzyme/Protease
  2. Acyltransferase
  3. ABT-046

ABT-046 

Cat. No.: HY-15197 Purity: 99.25%
Handling Instructions

ABT-046 is a potent, selective, and orally efficacious acyl CoA:diacylglycerol acyltransferase 1 (DGAT-1) inhibitor (IC50= 8 nM).

For research use only. We do not sell to patients.

ABT-046 Chemical Structure

ABT-046 Chemical Structure

CAS No. : 1031336-60-3

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 323 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 323 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 294 In-stock
Estimated Time of Arrival: December 31
10 mg USD 516 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1850 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2714 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Description

ABT-046 is a potent, selective, and orally efficacious acyl CoA:diacylglycerol acyltransferase 1 (DGAT-1) inhibitor (IC50= 8 nM)[1].

Molecular Weight

350.41

Formula

C₂₀H₂₂N₄O₂

CAS No.
SMILES

NC1=C(C2=CC=C([[email protected]]3CC[[email protected]](CC(O)=O)CC3)C=C2)C=NC4=CC=NN41

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 66.67 mg/mL (190.26 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8538 mL 14.2690 mL 28.5380 mL
5 mM 0.5708 mL 2.8538 mL 5.7076 mL
10 mM 0.2854 mL 1.4269 mL 2.8538 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.67 mg/mL (4.77 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.67 mg/mL (4.77 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Dilution Calculator

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Keywords:

ABT-046ABT046ABT 046AcyltransferaseDiacylglycerol acyltransferaseDiglyceride acyltransferaseacyl-CoA:cholesterol acyltransferasemono- acylglycerol acyltransferaseInhibitorinhibitorinhibit

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Product Name:
ABT-046
Cat. No.:
HY-15197
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