Afatinib impurity 3

Cat. No.: HY-Z3812 Purity: 98.0%: Data Sheet
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Afatinib impurity 3 is an impurity of Afatinib (HY-10261).

For research use only. We do not sell to patients.

Afatinib impurity 3 Chemical Structure

CAS No. : 945553-91-3

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
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Description

Afatinib impurity 3 is an impurity of Afatinib (HY-10261).

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	IC₅₀	<0.001 μM Compound: BIBW2992	Antiproliferative activity against human A-431 cells harboring wild type EGFR assessed as inhibition of cell proliferation incubated for 72 hrs by sulforhodamine B colorimetric assay Antiproliferative activity against human A-431 cells harboring wild type EGFR assessed as inhibition of cell proliferation incubated for 72 hrs by sulforhodamine B colorimetric assay	[PMID: 28987609]
A549	IC₅₀	0.71 μM Compound: 3	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 29775935]
BT-474	IC₅₀	54 nM Compound: 34; BIBW2992	Antiproliferative activity against human BT474 cells expressing wild type HER2 incubated for 72 hrs by MTS assay Antiproliferative activity against human BT474 cells expressing wild type HER2 incubated for 72 hrs by MTS assay	[PMID: 28754471]
MCF7	IC₅₀	0.93 μM Compound: 3	Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 29775935]
NCI-H1975	IC₅₀	0.495 μM Compound: BIBW2992	Antiproliferative activity against human NCI-H1975 cells harboring EGFR L858R/T790M double mutant assessed as inhibition of cell proliferation incubated for 72 hrs by sulforhodamine B colorimetric assay Antiproliferative activity against human NCI-H1975 cells harboring EGFR L858R/T790M double mutant assessed as inhibition of cell proliferation incubated for 72 hrs by sulforhodamine B colorimetric assay	[PMID: 28987609]
NCI-H1975	IC₅₀	92 nM Compound: 34; BIBW2992	Antiproliferative activity against human NCI-H1975 cells expressing EGFR T790M/L858R mutant incubated for 72 hrs by MTS assay Antiproliferative activity against human NCI-H1975 cells expressing EGFR T790M/L858R mutant incubated for 72 hrs by MTS assay	[PMID: 28754471]
PC-3	IC₅₀	2.51 μM Compound: 3	Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay	[PMID: 29775935]

Molecular Weight

485.94

Formula

C₂₄H₂₅ClFN₅O₃

CAS No.

945553-91-3

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1O[C@H]4COCC4)/C=C/CN(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Purity: 99.55%

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Data Sheet (244 KB) SDS (393 KB)

COA (254 KB) HNMR (130 KB) LCMS (289 KB)

Handling Instructions (2659 KB)