AIE-GA 

AIE-GA is a Golgi apparatus (GA) fluorescent probe (green channel: λex = 405 nm, λem = 500-700 nm). AIE-GA has a favourable binding ability to interact with COX-2. AIE-GA binds to the cyclooxygenase catalytic site of COX-2^[1].

For Golgi apparatus staining, cells were first incubated with ACQ-GA (2 μM) and AIE-GA (2 μM), respectively. Then Golgi Tracker Red (333 μg/mL) was added and incubated at 37 °C for 30 min, and the medium was removed and the cells were rinsed with phosphate buffered saline (PBS) three times and then imaged under a confocal microscope^[1].
Loss in fluorescence of HeLa cells stained with ACQ-GA (2 μM), AIE-GA (2 μM) and Golgi Tracker Red (333 μg/mL) with increasing the number of scans of laser irradiation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

527.64

C₃₃H₂₅N₃O₂S

2653341-16-1

N#C/C(C1=CC=C(C2=CC=C(S(N)(=O)=O)C=C2)C=C1)=C\C3=CC=C(N(C4=CC=CC=C4)C5=CC=CC=C5)C=C3

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• [1]. Xiao P, et al. An aggregation-induced emission platform for efficient Golgi apparatus and endoplasmic reticulum specific imaging. Chem Sci. 2021 Oct 5;12(41):13949-13957.  [Content Brief]