Altemicidin
Altemicidin is a monoterpene alkaloid originally isolated from S. sioyaensis with acaricidal and anticancer activities. It is acaricidal to two-spotted spider mites (T. urticae) in a greenhouse pot test at concentrations of 10 and 100 ppm. Altemicidin inhibits the growth of murine L1210 lymphocytic leukemia and IMC carcinoma cells (IC50s=0.84 and 0.82 μg/mL, respectively). It is toxic to mice with an LD50 value of 0.3 mg/kg.
For research use only. We do not sell to patients.
- CAS No.: 125399-82-8
- Formula: C13H20N4O7S
- Molecular Weight:376.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| L1210 | IC50 |
0.84 μM
Compound: 9
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Antiproliferative activity against mouse L1210 cells assessed as inhibition of cell proliferation incubated for 48 hrs by Coulter counter method
Antiproliferative activity against mouse L1210 cells assessed as inhibition of cell proliferation incubated for 48 hrs by Coulter counter method
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[PMID: 33160760] |
| L1210 | IC50 |
2.12 μM
Compound: 1
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Cytotoxicity against mouse L1210 cells assessed as growth inhibition after 48 hrs by coulter counter analysis
Cytotoxicity against mouse L1210 cells assessed as growth inhibition after 48 hrs by coulter counter analysis
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[PMID: 26035239] |
Chemical Information
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CAS No. 125399-82-8
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Molecular Weight 376.39
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Formula C13H20N4O7S
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SMILES
O=C(C[S](N)(=O)=O)N[C@@]1([C@@](CN2C)([H])[C@@](C(C(N)=O)=C2)([H])C[C@@H]1O)C(O)=O
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Synonyms
(-)-Altemicidin
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Acute Systemic Toxicity Study
Acute systemic toxicity studies evaluate adverse effects occurring after a single exposure, or repeated exposure within a short acute window, and the main in vivo readouts are mortality, moribund condition, clinical signs, body-weight change, and gross pathological findings; acute oral toxicity methods were developed to replace classical LD50 testing with reduced-animal designs such as fixed-dose procedure, acute toxic class method, and up-and-down procedure. The fixed-dose procedure classifies acute toxicity by administering predefined dose levels and observing evident toxicity rather than using death as the primary endpoint, whereas the acute toxic class method uses sequential groups of three animals per step and the up-and-down procedure doses animals sequentially to estimate an LD50 with fewer animals than conventional LD50 testing.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Altemicidin Related Classifications
HY-N10653 Related Classifications
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