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Cat. No.: HY-162261

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Antibacterial agent 186

Antibacterial agent 186 (compound 25) is a potent antibacterial agent. Antibacterial agent 186 shows antibiofilm-forming properties against clinical Staphylococcus epidermidis strains and demonstrates the capacity to eliminate existing biofilm layers. Antibacterial agent 186 has the potential for the research of multidrug-resistant Staphylococcus epidermidis.

For research use only. We do not sell to patients.

Formula: C₂₆H₂₇ClF₃N₃O₂S
Molecular Weight:538.02

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Antibacterial agent 186 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
BJ	IC₅₀	13.2 μg/mL Compound: 25	Cytotoxicity against human BJ cells incubated for 24 hrs by MTT assay Cytotoxicity against human BJ cells incubated for 24 hrs by MTT assay	[PMID: 38505856]
H9c2	IC₅₀	26.9 μg/mL Compound: 25	Cytotoxicity against rat H9c2 cells incubated for 24 hrs by MTT assay Cytotoxicity against rat H9c2 cells incubated for 24 hrs by MTT assay	[PMID: 38505856]

In Vitro

Antibacterial agent 186 (compound 25) shows bacteriostatic activity against clinical multidrug-resistant S. epidermidis strains with MIC₅₀ value of 1.6 μg/mL and MIC₉₀ value of 3.125 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 538.02
Formula C₂₆H₂₇ClF₃N₃O₂S
SMILES

O=C(NC1CCN(CCC(C2=CC=CS2)OC3=CC=C(C=C3)C(F)(F)F)CC1)NC4=CC(Cl)=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Vittorio Canale, et al. Improving Activity of New Arylurea Agents against Multidrug-Resistant and Biofilm-Producing Staphylococcus epidermidis. ACS Med. Chem. Lett. 2024.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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