Antibacterial agent 347 

Antibacterial agent 347 (Compound 4d) is an Antibacterial agent. Antibacterial agent 347 exhibits selective antibacterial activity against Streptococcus mutans. Antibacterial agent 347 shows moderate ABTS•⁺ free radical scavenging activity^[1].

Antibacterial agent 347 (25 μg/mL starting concentration; 24 h) potently and selectively inhibits Streptococcus mutans ATCC 25175 growth with an MIC of 1.56 μg/mL and an MBC of 3.12 μg/mL, while showing no activity against seven other tested bacterial strains^[1].
Antibacterial agent 347 (MIC/2-MIC/8; 24 h) exhibits dose-dependent anti-biofilm activity against Streptococcus mutans at sub-MIC concentrations, with significant biofilm formation reduction at MIC/2, MIC/4, and MIC/8^[1].
Antibacterial agent 347 (25 μg/mL; 5 days) inhibits mycelium growth of Alternaria alternata ATCC 6663 by 42.50%, Fusarium moniliforme NRRL 2374 by 33.81%, Botrytis cinerea AHU 9424 by 26.30%, and shows minimal inhibition (1.12%) of Fusarium culmorum NRRL 3288 at 25 μg/mL^[1].
Antibacterial agent 347 exhibits moderate ABTS•+ free radical scavenging activity with an IC₅₀ of 24.21 μg/mL^[1].
Antibacterial agent 347 (30 min) exhibits DPPH• free radical scavenging activity with an IC₅₀ of 37.87 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

352.43

C₁₇H₁₂N₄OS₂

CC(N=NS1)=C1C(O2)=NN=C2C3=CC=C(SC4=CC=CC=C4)C=C3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kurtuluş İG, et al. Novel 1,2,3-Thiadiazole-based Hydrazone and 1,3,4-Oxadiazole hybrids as promising agents against Streptococcus mutans: Synthesis, biological evaluation, and molecular modeling studies. Bioorg Chem. 2026;177:109935.