CD116 Antibody (YA6932)
(Synonyms: CD_antigen=CD116 antibody)CD116 Antibody (YA6932) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD116.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human
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Formulation:
Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:500 | 1:1000 | 1:50 |
Product Details
CD116 Antibody (YA6932) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD116.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 50 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size：46 kDa
Recombinant protein within Human CD116 aa 23-122 / 400.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
GM-CSF R alpha (CD116) is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2. GM-CSF R alpha binds to the cytokine with high specificity and low affinity[1]. GM-CSF R alpha binds to GM-CSF and induces cell differentiation[2]. GM-CSF R alpha monoclonal antibody decreases GM-CSFRα expression on GM-CSF-responsive cells and shows anti-inflammatory activity in rheumatoid arthritis (RA)[3].
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Subcellular Localization
Cell membrane,Secreted,Secreted,Secreted
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Isoforms & Post-Translational Modification
CD116 has 8 isomers: P15509-1: 46207 Da (predicted); P15509-2: 46901 Da (predicted); P15509-3: 38439 Da (predicted); P15509-4: 32915 Da (predicted); P15509-5: 43545 Da (predicted); P15509-6: 26648 Da (predicted); P15509-7: 49944 Da (predicted); P15509-8: 31101 Da (predicted).
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Subunit
Heterodimer of an alpha and a beta subunit
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SwissProt ID
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Synonyms
CD_antigen=CD116 antibody
Documentation
[1]. Hansen G, et al. The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation. Cell. 2008 Aug 8;134(3):496-507. [Content Brief]
[2]. Lotfi N, et al. Roles of GM-CSF in the Pathogenesis of Autoimmune Diseases: An Update. Front Immunol. 2019 Jun 4;10:1265. [Content Brief]
[3]. Cook AD, et al. Granulocyte macrophage colony-stimulating factor receptor α expression and its targeting in antigen-induced arthritis and inflammation. Arthritis Res Ther. 2016 Dec 1;18(1):287. [Content Brief]
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