CD46 Antibody (YA3811)

Cat. No.: HY-P84114: Data Sheet User Guide for Antibodies
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CD46 Antibody (YA3811) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD46.

For research use only. We do not sell to patients.

Size	Stock	Quantity
20 μL	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL	Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

CD46 Antibody (YA3811) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD46.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 44 kDa;

Observed band size: 50-70 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

P15529

Gene ID

4179 [NCBI]

Immunogen

Purified recombinant fragment of human CD46 (AA: extra 35-179) expressed in E. Coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1:1000
FC FC: Flow Cytometry	1:200-1:400
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS with 0.05% sodium azide

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity; (Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells; (Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3; (Microbial infection) Acts as a receptor for cultured Measles virus; (Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6; (Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes (PubMed:11260136, PubMed:11971006, PubMed:7708671, PubMed:9379894)

Subcellular Localization：Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein

Expression：
Tissue_specificity:Except for red blood cells, all cells express [the following].

Isoforms & Post-Translational Modification：P15529 has 16 isomers: P15529-1: 43747 Da (predicted); P15529-2: 44238 Da (predicted); P15529-11: 42248 Da (predicted); P15529-3: 42738 Da (predicted); P15529-12: 40868 Da (predicted); P15529-4: 41359 Da (predicted); P15529-13: 42193 Da (predicted); P15529-5: 42683 Da (predicted); P15529-14: 40693 Da (predicted); P15529-6: 41183 Da (predicted); P15529-15: 39313 Da (predicted); P15529-7: 39804 Da (predicted); P15529-8: 40705 Da (predicted); P15529-9: 39325 Da (predicted); P15529-10: 43286 Da (predicted); P15529-16: 36826 Da (predicted).
N-glycosylated on Asn-83; Asn-114 and Asn-273 in most tissues, but probably less N-glycosylated in testis. N-glycosylation on Asn-114 and Asn-273 is required for cytoprotective function. N-glycosylation on Asn-114 is required for Measles virus binding. N-glycosylation on Asn-273 is required for Neisseria binding. N-glycosylation is not required for human adenovirus binding;Extensively O-glycosylated in the Ser/Thr-rich domain. O-glycosylation is required for Neisseria binding but not for Measles virus or human adenovirus binding;In epithelial cells, isoforms B/D/F/H/J/L/3 are phosphorylated by YES1 in response to infection by Neisseria gonorrhoeae; which promotes infectivity. In T-cells, these isoforms may be phosphorylated by LCK

Subunit：Interacts with C3b (PubMed:1717583, PubMed:3260937). Interacts with C4b (PubMed:1717583). Interacts with moesin/MSN (PubMed:7884872)

Synonyms

MCP; TLX; AHUS2; MIC10; TRA2.10

Documentation

User Guide for Antibodies (1077 KB)