CD46 Antibody (YA3811)
(Synonyms: MCP; TLX; AHUS2; MIC10; TRA2.10)CD46 Antibody (YA3811) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD46.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
CD46 Antibody (YA3811) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD46.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 50-70 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 44 kDa
Purified recombinant fragment of human CD46 (AA: extra 35-179) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD46 acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity; (Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells; (Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3; (Microbial infection) Acts as a receptor for cultured Measles virus; (Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6; (Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes[1][2][3][4].
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Subcellular Localization
Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein
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Expression
Tissue_specificity:Except for red blood cells, all cells express [the following]. -
Isoforms & Post-Translational Modification
P15529 has 16 isomers: P15529-1: 43747 Da (predicted); P15529-2: 44238 Da (predicted); P15529-11: 42248 Da (predicted); P15529-3: 42738 Da (predicted); P15529-12: 40868 Da (predicted); P15529-4: 41359 Da (predicted); P15529-13: 42193 Da (predicted); P15529-5: 42683 Da (predicted); P15529-14: 40693 Da (predicted); P15529-6: 41183 Da (predicted); P15529-15: 39313 Da (predicted); P15529-7: 39804 Da (predicted); P15529-8: 40705 Da (predicted); P15529-9: 39325 Da (predicted); P15529-10: 43286 Da (predicted); P15529-16: 36826 Da (predicted).
N-glycosylated on Asn-83; Asn-114 and Asn-273 in most tissues, but probably less N-glycosylated in testis. N-glycosylation on Asn-114 and Asn-273 is required for cytoprotective function. N-glycosylation on Asn-114 is required for Measles virus binding. N-glycosylation on Asn-273 is required for Neisseria binding. N-glycosylation is not required for human adenovirus binding;Extensively O-glycosylated in the Ser/Thr-rich domain. O-glycosylation is required for Neisseria binding but not for Measles virus or human adenovirus binding;In epithelial cells, isoforms B/D/F/H/J/L/3 are phosphorylated by YES1 in response to infection by Neisseria gonorrhoeae; which promotes infectivity. In T-cells, these isoforms may be phosphorylated by LCK -
Subunit
Interacts with C3b (PubMed:1717583, PubMed:3260937). Interacts with C4b (PubMed:1717583). Interacts with moesin/MSN (PubMed:7884872)
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SwissProt ID
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Synonyms
MCP; TLX; AHUS2; MIC10; TRA2.10
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