CHMP5 Antibody (YA8092)(PBS only)

Cat. No.: HY-P88408A: Data Sheet User Guide for Antibodies
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CHMP5 Antibody (YA8092) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CHMP5.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

CHMP5 Antibody (YA8092) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CHMP5.

Host

Mouse

Molecular Weight

Predicted band size: 24.4 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q9NZZ3

Immunogen

Full length human recombinant protein of human CHMP5 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses) (PubMed:14519844). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release (PubMed:14519844)

Subcellular Localization：Cytoplasm, cytosol,Endosome membrane,Midbody

Expression：Induction: Up-regulated by muramyl-dipeptide and lipopolysaccharide

Isoforms & Post-Translational Modification：Q9NZZ3 has two isomers: Q9NZZ3-1: 24571 Da (predicted); Q9NZZ3-2: 19520 Da (predicted).
(Microbial infection) Stearoylated By S丨ISGylated

Subunit：Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III)

Synonyms

C9orf83; CGI-34; HSPC177; PNAS-2; SNF7DC2; Vps60

Documentation

User Guide for Antibodies (1077 KB)