CLEC4E Antibody (YA8006)(PBS only)
(Synonyms: CLECSF9; MINCLE)CLEC4E Antibody (YA8006) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CLEC4E.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, IHC-P, FC
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:2000 | 1:150 | 1:100 |
Product Details
CLEC4E Antibody (YA8006) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CLEC4E.
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Host Mouse
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 24.9 kDa
Full length human recombinant protein of human CLEC4E produced in HEK293T cell.
Affinity purified
Non-conjugated
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CLEC4E is a Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of abnormal self and pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs notably include mycobacterial trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid with potent adjuvant immunomodulatory functions. Interacts with signaling adapter Fc receptor gamma chain/FCER1G to form a functional complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. Also recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia and mediates macrophage activation. Through recognition of DAMPs released upon nonhomeostatic cell death, enables immune sensing of damaged self and promotes inflammatory cell infiltration into the damaged tissue[1][2][3].
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Subcellular Localization
Cell membrane,Cell projection, phagocytic cup
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Expression
Tissue_Specificity: Expressed in monocytes and macrophages -
Isoforms & Post-Translational Modification
Q9ULY5: 219 amino acids, molecular weight 25073 Da.
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Subunit
Monomer and homodimer (PubMed:18509109)
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SwissProt ID
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Synonyms
CLECSF9; MINCLE
Documentation
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