DOCK 7 Antibody (YA8902)
(Synonyms: dedicator of cytokinesis 7, ZIR2)
Based on 1 Customer Validation
DOCK 7 Antibody (YA8902) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DOCK 7.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB, ICC/IF, IF-Tissue, IP, ELISA
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Reactivity :
human, mouse, rat
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Formulation:
Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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IP
IP: Immunoprecipitation
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|---|
| Dilution Ratio | 1:100-1000 | 1:50-500 | 1:50-500 | 1-2μg per 100-500μg Total protein | 1:30-3000 |
Product Details
DOCK 7 Antibody (YA8902) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DOCK 7.
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Host Mouse
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Species Reactivityhuman, mouse, rat
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Calculated Molecular Weight Predicted band size: 242 kDa
A synthesized peptide derived from human DOCK 7.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at 2-8°C for 1 year, do not freeze.
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Shipping
Shipping with blue ice.
Background
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Function
DOCK 7 functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization. As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity)[1][2].
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Subcellular Localization
Cell projection, axon
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Expression
Tissue_Specificity: Widely expressed. -
Isoforms & Post-Translational Modification
DOCK 7 has 7 isoforms, Q96N67-1: amino acid length is 2140, molecular weight is 242561 Da (predicted); Q96N67-2: amino acid length is 2129, molecular weight is 241412 Da (predicted); Q96N67-3: amino acid length is 2100, molecular weight is 238534 Da (predicted); Q96N67-4: amino acid length is 2098, molecular weight is 238274 Da (predicted); Q96N67-5: amino acid length is 2109, molecular weight is 239422 Da (predicted); Q96N67-6: amino acid length is 2131, molecular weight is 241673 Da (predicted); Q96N67-7: amino acid length is 632, molecular weight is 72236 Da (predicted).
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Subunit
Component of the DOCK7-induced septin displacement/DISP complex, at least composed of DOCK7, LRCH3 and MYO6.
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SwissProt ID
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Synonyms
dedicator of cytokinesis 7, ZIR2
Documentation
[1]. Watabe-Uchida M, et al. The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18. Neuron. 2006 Sep 21;51(6):727-39. [Content Brief]
[2]. O'Loughlin T, et al. The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics. EMBO Rep. 2018 Apr;19(4):. [Content Brief]
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