FES Antibody (YA4851)

Cat. No.: HY-P85159: Data Sheet User Guide for Antibodies
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FES Antibody (YA4851) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to FES.

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사이즈		재고
50 μL		견적 받기
100 μL		견적 받기

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
제품 설명

제품 설명

FES Antibody (YA4851) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to FES.

Host

Mouse

Clonality

Monoclonal

분자량

Predicted band size: 93 kDa;

Species Reactivity

Human

SwissProt ID

P07332

Gene ID

2242 [NCBI]

Immunogen

Purified recombinant fragment of Fer expressed in E. Coli.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:2000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1:1000
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:50-200

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified

Appearance

Liquid

Formulation

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

선적

Shipping with blue ice.

Background

Function：Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28

Subcellular Localization：Cytoplasm, cytosol; Cytoplasm, cytoskeleton; Cell membrane; Peripheral membrane protein; Cytoplasmic side; Cytoplasmic vesicle; Golgi apparatus; Cell junction, focal adhesion

Expression：
Tissue_specificity:Widely expressed. Detected in adult colonic epithelial cells (protein level) (PubMed:16455651, PubMed:19051325) . Expressed in melanocytes (protein level) (PubMed:28463229) .

Isoforms & Post-Translational Modification：P07332 has 4 isomers: P07332-1: 93497 Da (predicted); P07332-2: 78633 Da (predicted); P07332-3: 86663 Da (predicted); P07332-4: 85466 Da (predicted).
Autophosphorylated on Tyr-713. Phosphorylated by LYN in response to FCER1 activation. Phosphorylated by HCK

Subunit：Homooligomer. Interacts with BCR. Interacts (when activated, via coiled coil domain) with TRIM28. Interacts (via SH2 domain) with phosphorylated EZR, MS4A2/FCER1B and HCLS1/HS1. Interacts with phosphorylated KIT. Interacts with FLT3. Interacts (via F-BAR domain) with soluble tubulin. Interacts (via SH2 domain) with microtubules

Synonyms

FES; FPS; Tyrosine-protein kinase Fes/Fps; Feline sarcoma/Fujinami avian sarcoma oncogene homolog; Proto-oncogene c-Fes; Proto-oncogene c-Fps; p93c-fes

각종 서류

User Guide for Antibodies (1077 KB)