PDE4A Antibody (YA7841)
(Synonyms: DPDE2; PDE4; PDE46)
Based on 1 Customer Validation
PDE4A Antibody (YA7841) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PDE4A.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, IHC-P, ICC/IF, FC
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Reactivity :
Human, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|---|
| Dilution Ratio | 1:2000 | 1:50-250 | 1:100-250 | 1:100 |
Product Details
PDE4A Antibody (YA7841) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PDE4A.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Rat
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Calculated Molecular Weight Predicted band size: 72.0 kDa
Full length human recombinant protein of human PDE4A produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PDE4A hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes|Efficiently hydrolyzes cAMP|Efficiently hydrolyzes cAMP|Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP|Efficiently hydrolyzes cAMP|Efficiently hydrolyzes cAMP|Efficiently hydrolyzes cAMP
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Subcellular Localization
Cytoplasm, perinuclear region,Cytoplasm, perinuclear region,Cell projection, ruffle membrane,Cytoplasm, cytosol,Membrane,Cytoplasm, perinuclear region,Cytoplasm, cytosol,Membrane
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Expression
Tissue_Specificity: Expressed in lymphoid cell subsets including CD8-positive T cells and T-helper 2 cells. Expressed in dendritic cells|Highly expressed in liver, stomach, testis, thyroid and adrenal glands and at a lower extent in placenta, kidney, pancreas, ovary, uterus and skin. Expressed in myeloid cell subsets including dendritic cells, monocytes, macrophages, eosinophils and mast cells. Expressed in natural killer cells. Expressed in bronchial smooth muscle|Expressed at high levels in the heart and small intestine. It is also found in the brain, kidney, spleen, colon, salivary gland, ovary and peripheral blood lymphocytes|Expressed predominantly in skeletal muscle and brain and at lower levels in the testis. Found in specific neuronal subpopulations including cortical pyramidal neurons, horn neurons in the spinal cord and Purkinje cells in cerebellum (at protein level) -
Isoforms & Post-Translational Modification
P27815 has 7 isomers: P27815-1: 98143 Da (predicted); P27815-2: 95236 Da (predicted); P27815-3: 76380 Da (predicted); P27815-4: 72222 Da (predicted); P27815-5: 36706 Da (predicted); P27815-6: 91323 Da (predicted); P27815-7: 95571 Da (predicted).
Proteolytically cleaved by CASP3丨Phosphorylated at Ser-119 by PKA -
Subunit
Interacts with LYN (via SH3 domain)
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SwissProt ID
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Synonyms
DPDE2; PDE4; PDE46
Documentation
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