PDE4A Antibody (YA7841)

Cat. No.: HY-P88157: Ficha de datos COA
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PDE4A Antibody (YA7841) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PDE4A.

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Tamaño	Stock	Cantidad
20 μL	En stock	Estimated Time of Arrival: December 31
50 μL	En stock	Estimated Time of Arrival: December 31
100 μL	En stock	Estimated Time of Arrival: December 31
250 μL	Obtener un presupuesto

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Descripciòn

Descripciòn

PDE4A Antibody (YA7841) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PDE4A.

Host

Mouse

Clonality

Monoclonal

Peso molecular

Predicted band size: 72.0 kDa

Species Reactivity

Human, Rat

SwissProt ID

P27815

Immunogen

Full length human recombinant protein of human PDE4A produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:2000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-250
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-250
FC FC: Flow Cytometry	1:100

Sensitivity	Endogenous	Pureza	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Envío

Shipping with blue ice.

Background

Function：Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes|Efficiently hydrolyzes cAMP|Efficiently hydrolyzes cAMP|Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP|Efficiently hydrolyzes cAMP|Efficiently hydrolyzes cAMP|Efficiently hydrolyzes cAMP

Subcellular Localization：Cytoplasm, perinuclear region,Cytoplasm, perinuclear region,Cell projection, ruffle membrane,Cytoplasm, cytosol,Membrane,Cytoplasm, perinuclear region,Cytoplasm, cytosol,Membrane

Expression：
Tissue_Specificity: Expressed in lymphoid cell subsets including CD8-positive T cells and T-helper 2 cells. Expressed in dendritic cells|Highly expressed in liver, stomach, testis, thyroid and adrenal glands and at a lower extent in placenta, kidney, pancreas, ovary, uterus and skin. Expressed in myeloid cell subsets including dendritic cells, monocytes, macrophages, eosinophils and mast cells. Expressed in natural killer cells. Expressed in bronchial smooth muscle|Expressed at high levels in the heart and small intestine. It is also found in the brain, kidney, spleen, colon, salivary gland, ovary and peripheral blood lymphocytes|Expressed predominantly in skeletal muscle and brain and at lower levels in the testis. Found in specific neuronal subpopulations including cortical pyramidal neurons, horn neurons in the spinal cord and Purkinje cells in cerebellum (at protein level)

Isoforms & Post-Translational Modification：P27815 has 7 isomers: P27815-1: 98143 Da (predicted); P27815-2: 95236 Da (predicted); P27815-3: 76380 Da (predicted); P27815-4: 72222 Da (predicted); P27815-5: 36706 Da (predicted); P27815-6: 91323 Da (predicted); P27815-7: 95571 Da (predicted).
Proteolytically cleaved by CASP3丨Phosphorylated at Ser-119 by PKA

Subunit：Interacts with LYN (via SH3 domain)

Synonyms

DPDE2; PDE4; PDE46

Documentación

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Ficha de datos (231 KB) SDS (251 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)