SAMM50 Antibody (YA9645)
(Synonyms: CGI 51 antibody; CGI-51 antibody; FLJ35825 antibody; FLJ42905 antibody; FLJ99036 antibody; OMP85 antibody; SAM50 antibody; SAM50_HUMAN antibody; Samm50 antibody; sorting and assembly machinery 50kDa antibody; CGI 51 antibody; CGI-51 antibody; FLJ35825 antibody; FLJ42905 antibody; FLJ99036 antibody; OMP85 antibody; SAM50 antibody; SAM50_HUMAN antibody; Samm50 antibody; sorting and assembly machinery 50kDa antibody; sorting and assembly machinery component 50 homolog (S. cerevisiae) antibody; Sorting and assembly machinery component 50 homolog antibody; sorting and assembly machinery component 50, S. cerevisiae, homolog of antibody; TOB55 antibody; Transformation-related gene 3 protein antibody; TRG-3 antibody; YNL026W antibody; )SAMM50 Antibody (YA9645) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SAMM50.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human
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Formulation:
Supplied in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:100-1:200 |
Product Details
SAMM50 Antibody (YA9645) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SAMM50.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 52 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 52 kDa
A synthesized peptide derived from human SAMM50.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SAMM50 plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes. Required for the assembly of TOMM40 into the TOM complex[1][2][3].
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Subcellular Localization
Mitochondrion outer membrane; Cytoplasm; Mitochondrion
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Expression
PositiveControl: A431 cell lysate, HeLa cell lysate, C2C12 cell lysate, mouse pancreas tissue lysate, rat pancreas tissue lysate, human pancreas tissue, human kidney tissue. -
Isoforms & Post-Translational Modification
SAMM50 has an amino acid length of 469, molecular weight is 51976 Da.
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Subunit
Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13.
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SwissProt ID
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Synonyms
CGI 51 antibody; CGI-51 antibody; FLJ35825 antibody; FLJ42905 antibody; FLJ99036 antibody; OMP85 antibody; SAM50 antibody; SAM50_HUMAN antibody; Samm50 antibody; sorting and assembly machinery 50kDa antibody; CGI 51 antibody; CGI-51 antibody; FLJ35825 antibody; FLJ42905 antibody; FLJ99036 antibody; OMP85 antibody; SAM50 antibody; SAM50_HUMAN antibody; Samm50 antibody; sorting and assembly machinery 50kDa antibody; sorting and assembly machinery component 50 homolog (S. cerevisiae) antibody; Sorting and assembly machinery component 50 homolog antibody; sorting and assembly machinery component 50, S. cerevisiae, homolog of antibody; TOB55 antibody; Transformation-related gene 3 protein antibody; TRG-3 antibody; YNL026W antibody;
Documentation
References
[1]. Ott C, et al. Sam50 functions in mitochondrial intermembrane space bridging and biogenesis of respiratory complexes. Mol Cell Biol. 2012 Mar;32(6):1173-88. [Content Brief]
[2]. Ott C, et al. Detailed analysis of the human mitochondrial contact site complex indicate a hierarchy of subunits. PLoS One. 2015;10(3):e0120213. [Content Brief]
[3]. Humphries AD, et al. Dissection of the mitochondrial import and assembly pathway for human Tom40. J Biol Chem. 2005 Mar 25;280(12):11535-43. [Content Brief]
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